阿法骨化醇软胶囊对慢性阻塞性肺疾病患者免疫功能的临床研究

发布时间：2018-06-02 04:09

本文选题：阿法骨化醇软胶囊 + 免疫功能　；参考：《中国临床药理学杂志》2015年14期

【摘要】：目的评价阿法骨化醇软胶囊对慢性阻塞性肺疾病(COPD)患者免疫功能的影响。方法入选172例COPD患者,随机分成试验组86例和对照组86例,2组常规治疗相同(包括戒烟、支气管扩张剂、祛痰剂等),试验组口服阿法骨化醇软胶囊0.25μg,1天1次,治疗时间为6个月,比较2组治疗前后免疫功能(CD3+、CD4+、CD8+和CD4+/CD8+)、肺功能[用力肺活量(FVC)、第l秒用力呼气容积(FEV1)、FEV1/FVC、肺一氧化碳弥散量/肺泡容积(DLC0/VA)]及随访半年COPD急性发作情况。结果治疗后,试验组CD3+、CD4+、CD8+和CD4+/CD8+均较治疗前和对照组显著升高;治疗后,试验组FEV1、FEV1/FVC、DLCO/VA均显著高于治疗前和对照组(P0.05)。对照组治疗前后CD3+、CD4+、CD8+、CD4+/CD8+、FEV1、FEV1/FVC、DLCO/VA比较,差异无统计学意义(P0.05)。试验组6个月内COPD急性加重的发生率(9.30%)显著低于对照组(25.58%)(P0.05)。结论阿法骨化醇软胶囊可通过改善COPD患者免疫功能来改善肺功能,降低急性发作次数。
[Abstract]:Objective to evaluate the effect of Alfacalidol soft capsule on immune function in patients with chronic obstructive pulmonary disease (COPD). Methods 172 patients with COPD were randomly divided into two groups: the experimental group (n = 86) and the control group (n = 86) treated with the same routine therapy (including smoking cessation, bronchiectator, expectorant and so on). The treatment time was 6 months. The immune function of CD3, CD 4, CD 8, CD4 / CD 8, pulmonary function [forced vital capacity (FV), forced expiratory volume (FEV 1 / FVC), lung carbon monoxide diffusion volume (CO) / alveolar volume (DLC0% va)] and acute attack of COPD were compared before and after treatment. Results after treatment, the levels of CD3 CD 4, CD 8 and CD4 / CD 8 in the trial group were significantly higher than those in the control group and before treatment, and after the treatment, the FEV 1 / F V 1 / F V 1 / V C / V ratio VA in the trial group was significantly higher than that in the control group and before treatment (P 0.05). In the control group, there was no significant difference in FEV1 / FEV1 / FVC+ DLCO-VA before and after treatment with CD3, CD4 / CD8, CD4 / CD8 and FEV1 / FVCU DLCO-VA, there was no significant difference between the two groups (P 0.05). The incidence of acute exacerbation of COPD in the test group within 6 months was significantly lower than that in the control group (P 0.05). Conclusion Alfacalidol soft capsule can improve the lung function and reduce the acute attack times by improving the immune function of COPD patients.
【作者单位】：温岭市第一人民医院呼吸内科;
【基金】：浙江省科技计划基金资助项目(2010C33035)
【分类号】：R563.9

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