左氧氟沙星联合氨溴索治疗肺结核患者肺部感染的临床研究

发布时间：2018-06-04 10:59

本文选题：左氧氟沙星 + 氨溴索　；参考：《中华医院感染学杂志》2014年13期

【摘要】：目的探讨左氧氟沙星联合氨溴索治疗肺结核患者肺部感染的临床效果。方法选取2011年4月-2013年1月肺结核合并肺部感染患者136例,随机分为两组,其中对照组65例、观察组71例;两组患者均给予基础营养治疗和常规抗结核治疗,对照组患者同时给予左氧氟沙星静脉滴注,观察组患者给予左氧氟沙星静脉滴注的同时再给予氨溴索静脉滴注,对两组患者的治疗效果进行评价,记录两组患者痰液病原菌转阴时间和病灶吸收情况;采用SPSS13.0软件进行统计分析。结果肺结核合并肺部感染患者治疗显效率和总有效率观察组分别为61.97%和92.96%,对照组分别为47.69%和67.69%;观察组患者痰液病原菌转阴时间为(7.95±2.73)d,对照组为(11.47±3.20)d,观察组明显短于对照组;观察组病灶显著吸收和总吸收率分别为50.70%和84.51%,对照组分别为27.69%和61.54%,观察组患者明显高于对照组,上述比较两组差异有统计学意义(P0.05);两组患者均无严重不良反应发生。结论对肺结核合并肺部感染患者实施左氧氟沙星沙星联合氨溴索治疗安全而有效,而且用药简单,可以在临床工作中作为常规治疗方式进行推广。
[Abstract]:Objective to investigate the clinical effect of levofloxacin combined with ambroxol in the treatment of pulmonary infection in patients with pulmonary tuberculosis. Methods 136 patients with pulmonary tuberculosis complicated with pulmonary infection from April 2011 to January 2013 were randomly divided into two groups: the control group (n = 65) and the observation group (n = 71). The patients in the control group were given levofloxacin intravenous drip at the same time, and the patients in the observation group were given levofloxacin intravenous drip and ambroxol intravenous drip at the same time. The sputum negative time and lesion absorption of sputum were recorded and analyzed by SPSS13.0 software. Results the effective rate and total effective rate were 61.97% and 92.96 in the observation group, 47.69% and 67.69% in the control group, respectively, and the negative time of pathogenic bacteria in sputum was 7.95 卤2.73 days in the observation group and 11.47 卤3.20 days in the control group, which was significantly shorter than that in the control group. The significant absorption and total absorption rate were 50.70% and 84.51 in the observation group, 27.69% and 61.54 in the control group, respectively. The patients in the observation group were significantly higher than those in the control group, and the difference between the two groups was statistically significant (P 0.05), and no serious adverse reactions occurred in the two groups. Conclusion levofloxacin combined with ambroxol is safe and effective in the treatment of pulmonary tuberculosis patients with pulmonary infection.
【作者单位】：英德市人民医院感染科;英德市m[m8医院功能科;
【基金】：广东省卫生厅重点基金资助项目(GW-2010B-1023)
【分类号】：R521

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