老年慢性阻塞性肺疾病患者肺容量和弥散功能变化与疾病严重程度的关系

发布时间：2018-06-10 09:26

本文选题：慢性阻塞性肺疾病 + 肺容量　；参考：《中国老年学杂志》2017年17期

【摘要】：目的探讨老年慢性阻塞性肺疾病(COPD)患者肺容量和弥散功能变化与疾病严重程度的关系。方法老年COPD患者200例根据病情严重程度分成1级51例、2级61例、3级43例、4级45例,对比各组肺容量及弥散功能相关指标,分析患者各指标间的相关性。结果随着老年COPD患者疾病严重程度的加剧,其第1秒用力呼气容积(FEV1)、FEV1/用力肺活量(FVC)、峰值呼气流量(PEF)、最大呼气中段流量(MMEF)及一氧化碳的弥散量(DLCO)水平逐渐降低,而残气容积(RV)(体描)、RV/肺总量(TLC)(体描)、△TLC及△RV水平逐渐升高,差异有统计学意义(P0.05)。2~4级患者TLC(体描)水平明显高于1级患者,3~4级患者△RV/TLC水平明显高于1级及2级患者(P0.05)。患者的△TLC、△RV及RV/TLC(体描)均分别与FEV1、FEV1/FVC、PEF、MMEF呈负相关,DLCO分别与FEV1、FEV1/FVC、PEF、MMEF呈正相关。结论老年COPD患者的肺容量及弥散功能的改变与其疾病的严重程度之间具有紧密的关系,随着疾病严重程度的加剧,其肺容量及其弥散功能均会受到影响。
[Abstract]:Objective to investigate the relationship between pulmonary volume and diffusion function and severity of chronic obstructive pulmonary disease (COPD) in elderly patients. Methods according to the severity of the disease, 200 elderly patients with COPD were divided into 51 cases of grade 1, 61 cases of grade 2 and 43 cases of grade 3 and 45 cases of grade 4. The correlation of lung volume and diffusive function in each group was analyzed. Results with the exacerbation of the severity of the disease in the elderly patients with COPD, the forced expiratory volume (FEV1 / FEV1 / forced vital capacity), the peak expiratory flow (PEF), the maximum mid-expiratory flow (MMEF) and the diffusion volume of carbon monoxide (DLCO) decreased gradually in the first second. However, the RV / TLC level of RV / RV increased gradually, and the level of TLC was significantly higher in TLC than that in grade 1 and grade 2. The level of TLC was significantly higher than that in grade 1 and grade 2. The level of TLC was significantly higher in RV / TLC than that in grade 1 and grade 2. The level of TLC was significantly higher in RV / TLC than that in Grade 1 and Grade 2. The level of TLC was significantly higher in RV / TLC than that in Grade 1 and Grade 2. The level of TLC was significantly higher than that in Grade 1 and Grade 2. TLC, RV and RV / TLC were negatively correlated with FEV1 / FEV1 / FEV1 / FEV1 / PEFMEF, and DLCO was positively correlated with FEV1 / FEV1 / FVCtr / PEFFMEF respectively. Conclusion there is a close relationship between the changes of pulmonary volume and diffusion function and the severity of the disease in elderly patients with COPD. With the exacerbation of the severity of the disease, the pulmonary volume and diffusion function will be affected.
【作者单位】：中山大学附属第五医院呼吸内科;中山大学附属第五医院脑电图室;中山大学附属第五医院普外科;中山大学附属第五医院妇产科;
【分类号】：R563.9

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