体表电极代替多导食道电极测定慢性阻塞性肺疾病患者呼吸中枢驱动的可行性

发布时间：2018-06-15 23:22

本文选题：呼吸中枢驱动 + 等二氧化碳高通气　；参考：《实用医学杂志》2017年15期

【摘要】：目的探讨体表电极代替多导食道电极测定慢性阻塞性肺疾病(慢阻肺)患者呼吸中枢驱动的可行性。方法研究对象为呼吸科门诊29例稳定期中重度慢阻肺患者,均为男性,平均年龄(65.6±7.2)岁。采用体表电极和多导食道电极同时记录患者吸入支气管舒张剂前后静息状态和等二氧化碳高通气(MIV)时膈肌肌电和肺通气量的变化,比较两种方法测定的呼吸中枢驱动的差异。采用重复测量数据的方差分析,两两比较用最小LSD检验,相关分析采用Pearson检验。结果吸入支气管舒张剂后,患者静息和MIV时的肺通气量增加,体表电极和多导食道电极测定的呼吸中枢驱动均同步降低,呈显著相关(r=0.660,P0.01)。结论采取措施尽可能减少体表电极干扰的情况下,体表电极可以代替多导食道电极测定慢阻肺患者的呼吸中枢驱动。
[Abstract]:Objective to study the feasibility of using body surface electrode instead of multichannel esophageal electrode to measure respiratory center drive in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 29 moderate and severe COPD patients (mean age: 65.6 卤7.2) years were enrolled in this study. The changes of diaphragm electromyography and pulmonary ventilation volume during inhalation of bronchodiastolic agents and iso-carbon dioxide hyperventilation (MIV) were recorded by body surface electrode and multichannel electrode simultaneously. The difference of respiratory center drive between the two methods was compared. The variance analysis of repeated measurement data, the minimum LSD test for pairwise comparison, and Pearson test for correlation analysis were used. Results after inhaling bronchodiastolic agent, the pulmonary ventilation volume increased at rest and MIV, and the respiratory center drive measured by body surface electrode and multichannel esophagus electrode decreased synchronously, and there was a significant correlation between the lung ventilation volume and the respiratory center drive measured by body surface electrode and multichannel esophagus electrode. Conclusion when some measures are taken to minimize the interference of body surface electrodes, body surface electrodes can replace multichannel esophageal electrodes to determine the respiratory center drive in patients with chronic obstructive pulmonary disease.
【作者单位】：广州市番禺区中心医院呼吸内科;南方医科大学珠江医院呼吸内科;广州医科大学附属第一医院呼吸内科;
【基金】：广州市科技攻关专项基金资助(编号:201300000171) 广东省科技计划项目(编号:粤科[2013]137)
【分类号】：R563.9

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