慢性阻塞性肺疾病患者下呼吸道感染与25-羟基维生素D的关系研究

发布时间：2018-06-16 14:49

本文选题：-羟基维生素D + 慢性阻塞性肺疾病　；参考：《中华医院感染学杂志》2014年24期

【摘要】：目的研究慢性阻塞性肺疾病(COPD)患者25-羟基维生素D浓度与下呼吸道感染的关系,为临床治疗提供参考依据。方法收集2011年1月-2012年12月COPD患者126例,分为吸烟组76例、非吸烟组50例,并测定夏季和冬季的25-羟基维生素D浓度,同期选取50名健康人员为对照组,测定25-羟基维生素D浓度,采用SPSS13.0进行统计分析。结果 COPD患者夏季25-羟基维生素D浓度为(24.4±5.7)ng/ml,健康对照者夏季25-羟基维生素D浓度为(35.2±9.4)ng/ml;同季节吸烟组与非吸烟组25-羟基维生素D浓度差异无统计学意义,冬季COPD下呼吸道感染发生率高于夏季,同季节吸烟组下呼吸道感染发生率高于非吸烟组(P0.05)。结论 25-羟基维生素D浓度与慢性阻塞性肺疾病下呼吸道感染有一定关系,但其确切的关系有待深入研究。
[Abstract]:Objective to study the relationship between 25-hydroxyvitamin D concentration and lower respiratory tract infection in patients with chronic obstructive pulmonary disease (COPD). Methods 126 COPD patients from January 2011 to December 2012 were divided into smoking group (n = 76) and non-smoking group (n = 50). The concentrations of 25-hydroxyvitamin D in summer and winter were measured, and 50 healthy persons were selected as control group. The concentration of 25-hydroxyvitamin D was determined by SPSS 13.0. Results the concentration of 25-hydroxyvitamin D in COPD patients was 24.4 卤5.7 ng / ml in summer, and that in healthy controls was 35.2 卤9.4 ng / ml in summer, but there was no significant difference between smoking group and non-smoking group in the same season. The incidence of COPD lower respiratory tract infection in winter was higher than that in summer, and the incidence of lower respiratory tract infection in smoking group in the same season was higher than that in non-smoking group (P 0.05). Conclusion there is a certain relationship between 25-hydroxyvitamin D concentration and lower respiratory tract infection in chronic obstructive pulmonary disease, but its exact relationship needs further study.
【作者单位】：浙江省丽水学院医学院基础实验组;温州医科大学检验学院;
【基金】：浙江省自然科学基金资助项目(LY12H10003)
【分类号】：R563.9

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