住院肺结核患者病情转归的调查及相关因素分析

发布时间：2018-06-16 16:44

本文选题：肺结核 + 住院　；参考：《中华医院感染学杂志》2014年07期

【摘要】：目的对肺结核住院患者临床资料进行分析,并对治疗方法和治疗后的病情转归进行归纳总结,为临床资料提供参考依据。方法回顾性分析医院2008年1月-2011年12月683例肺结核住院患者的临床资料、用药情况、合并症及随访1年的临床转归等,对患者抗结核药物耐药性、治疗后临床转归及相关因素,采用SPSS12.0进行分析。结果多药耐药是肺结核住院患者的特征表型,占9.22%;伴发糖尿病的肺结核患者,在抗结核给药相同前提下,胰岛素治疗组1个月内转阴率为87.50%,明显高于口服降糖药物组的53.27%,20岁的青少年和80岁的老年肺结核患者病死率最高,分别为5.48%和14.06%,两组病死率差异无统计学意义。结论根据抗结核药物耐药测试制定个性化治疗方案,有助于降低住院肺结核患者抗结核药物耐药率,合并糖尿病、心血管疾病等并发症影响肺结核患者抗结核治疗的临床转归及预后。
[Abstract]:Objective to analyze the clinical data of inpatients with pulmonary tuberculosis (TB) and summarize the treatment methods and the outcome of the treatment so as to provide reference for the clinical data. Methods the clinical data, drug use, complications and clinical outcome of 1 year follow-up were retrospectively analyzed in 683 patients with pulmonary tuberculosis from January 2008 to December 2011. The drug resistance of the patients, the clinical outcome after treatment and the related factors were analyzed retrospectively. SPSS 12.0 was used for analysis. Results Multi-drug resistance (MDR) was the characteristic phenotype of inpatients with pulmonary tuberculosis (9.22%). The negative conversion rate in insulin treatment group was 87.50 in one month, which was significantly higher than that in oral hypoglycemic drug group (53.27 ~ 20 years old) and aged 80 years old patients with pulmonary tuberculosis (5.48% and 14.06%, respectively). There was no significant difference in mortality between the two groups. Conclusion it is helpful to reduce the rate of anti-tuberculosis drug resistance and to combine diabetes mellitus with individualized treatment according to the test of anti-tuberculosis drug resistance, which is helpful to reduce the rate of anti-tuberculosis drug resistance in patients with pulmonary tuberculosis. Cardiovascular disease and other complications affect the clinical outcome and prognosis of anti-tuberculosis treatment in pulmonary tuberculosis patients.
【作者单位】：湖州市中心医院感染内科;
【基金】：国家科技重大专项基金项目(2011ZX10004-901)
【分类号】：R521

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