肺功能非特异性表现120例临床分析

发布时间：2018-06-18 05:02

本文选题：肺疾病 + 肺总量　；参考：《重庆医学》2015年02期

【摘要】：目的对肺功能非特异性表现(NSP)患者的临床特点进行研究,为其临床研究提供可参考依据。方法选择2013年1月至2014年6月青岛经济技术开发区第一人民医院行肺功能检查的120例受试者作为研究对象,根据肺功能表现分为NSP组(n=20)与肺功能正常组(n=100),详细记录其肺功能指标,对其临床特点进行分析。并筛选出NSP发生的相关因素,应用Logistic回归分析进行多因素回归分析。结果正常组肺功能指标第一秒肺呼气容积(FEVl)、肺活量(VC)、肺总量(TLC)、用力肺活量(FVC)、最大自主通气量(MVV)、FEVl/FVC均明显高于NSP组,而RV/TCL低于NSP组,差异均有统计学意义(P0.05)。NSP组患者的临床可表现为阻塞性和(或)限制性疾病,但9例患者无肺部疾病。单因素分析显示NSP组年龄、BMI、吸烟史、吸烟量、阻塞性疾病、限制性疾病均明显高于正常组,两组比较差异有统计学意义(P0.05)。多因素分析显示年龄大、BMI高、既往吸烟史、存在阻塞性疾病及限制性疾病是NSP发生的独立危险因素(P0.05)。结论高龄、吸烟、肥胖可增加NSP发生的风险,临床上NSP可表现为阻塞性及限制性通气功能障碍的特点,在临床实际中需要积极鉴别。
[Abstract]:Objective to study the clinical characteristics of patients with non-specific pulmonary function (NSP) and to provide reference for clinical study. Methods from January 2013 to June 2014, 120 subjects who underwent pulmonary function examination in the first people's Hospital of Qingdao Economic and technological Development Zone were selected as the study subjects. According to the pulmonary function, the patients were divided into two groups: NSP group (n = 20) and normal group (n = 100). The indexes of lung function were recorded in detail and the clinical characteristics were analyzed. The factors related to the occurrence of NSP were screened, and logistic regression analysis was used to carry out multivariate regression analysis. Results in the normal group, the first second expiratory volume (FEVlV), vital capacity (VC), total lung volume (TLC), forced vital capacity (FV), maximal spontaneous ventilation (MVV) and FEVl / FVC were significantly higher than those in the NSP group, but RV / TCL was lower than that in the NSP group. There were significant differences in the clinical manifestations of obstructive and / or restrictive diseases in patients with P0.05. NSP, but there were no pulmonary diseases in 9 patients. Univariate analysis showed that BMI, smoking history, smoking volume, obstructive disease and restrictive disease in NSP group were significantly higher than those in normal group, and the difference between the two groups was statistically significant (P 0.05). Multivariate analysis showed that high BMI, smoking history, obstructive disease and restrictive disease were independent risk factors of NSP. Conclusion Old age, smoking and obesity may increase the risk of NSP, and the clinical features of NSP may be obstructive and restrictive ventilation dysfunction, which should be positively differentiated in clinical practice.
【作者单位】：青岛经济技术开发区第一人民医院呼吸内科;北京大学第三医院呼吸科;
【基金】：国家自然科学基金资助项目(30871127)
【分类号】：R563.9

【参考文献】