糖肽类抗菌药物治疗老年患者肺部感染的临床研究

发布时间：2018-06-18 23:00

本文选题：老年患者 + 肺部感染　；参考：《中华医院感染学杂志》2015年22期

【摘要】：目的探究糖肽类抗菌药物治疗老年患者耐甲氧西林金黄色葡萄球菌(MRSA)肺部感染的临床效果及安全性,为临床治疗提供参考依据。方法选取2012年1月-2013年1月住院治疗的112例MRSA肺部感染老年患者,其中73例使用万古霉素治疗,39例使用替考拉宁治疗,比较老年MRSA肺部感染患者两种抗菌药物治疗前后临床症状改善、细菌清除率、不良反应,分析两种抗菌药物在治疗MRSA的疗效。结果使用万古霉素和替考拉宁治疗MRSA后的总有效率比较、细菌清除率比较差异无统计学意义;治疗时间比较差异有统计学意义(t=6.4293,P0.05);治疗过程中出现胃肠反应、丙氨酸氨基转移酶(ALT)升高、肾毒性等,经对症处理后不良反应均治愈。结论合理使用万古霉素或替考拉宁对于老年MRSA肺部感染患者的治疗效果良好,治疗过程中未出现严重不良反应,安全可靠。
[Abstract]:Objective to investigate the clinical efficacy and safety of glycopeptide antibiotics in the treatment of pulmonary infection in elderly patients with methicillin-resistant staphylococcus aureus. Methods 112 elderly patients with MRSA pulmonary infection were selected from January 2012 to January 2013, 73 of whom were treated with vancomycin and 39 with teicoplanin. To compare the improvement of clinical symptoms, bacterial clearance rate and adverse reactions before and after treatment of two antibiotics in elderly patients with pulmonary infection of MRSA, and to analyze the efficacy of the two antibiotics in the treatment of MRSA. Results the total effective rate of vancomycin and teicoplanin in the treatment of MRSA was higher than that in the control group. There was no significant difference in bacterial clearance rate, there was significant difference in treatment time between vancomycin and teicoplanin in the treatment of MRSA, and there was gastrointestinal reaction in the course of treatment. Alanine aminotransferase (alt) increased, nephrotoxicity and other adverse reactions were cured after symptomatic treatment. Conclusion the reasonable use of vancomycin or teicoplanin is effective in the treatment of elderly patients with MRSA pulmonary infection.
【作者单位】：昆明医科大学第二附属医院干部医疗二科;襄阳市中心医院呼吸内科;襄阳市中心医院心内三病区;杭州市第六人民医院呼吸内科;
【基金】：浙江省医药卫生基金资助项目(2011KYB072)
【分类号】：R563.1

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