两性霉素B脂质体与伏立康唑治疗侵袭性肺曲霉菌病临床对比观察

发布时间：2018-06-23 07:04

本文选题：侵袭性肺曲霉菌病 + 两性霉素B脂质体　；参考：《山东医药》2016年04期

【摘要】：目的对比观察伏立康唑与两性霉素B脂质体治疗侵袭性肺曲霉菌病的效果和不良反应。方法研究对象为62例疑似或确诊侵袭性肺曲霉菌病患者,根据治疗药物不同分为伏立康唑组28例、两性霉素B脂质体组34例。伏立康唑组首日给予负荷剂量伏立康唑,6 mg/kg、2次/d;此后给予维持剂量,即3 mg/kg、2次/d。两性霉素B脂质体组给予两性霉素B脂质体治疗,起始剂量及维持剂量均为0.3 mg/kg、1次/d。有明确病原学证据时伏立康唑组剂量增至4 mg/kg、2次/d,两性霉素B组剂量增至0.6 mg/kg、1次/d。比较两组治疗效果及不良反应。结果伏立康唑组及两性霉素B组治愈率分别为28.6%、44.1%,P0.05;总有效率分别为42.8%、58.8%,P0.05。伏立康唑组用药期间未出现肾功能损害,两性霉素B脂质体组出现肾功能损害3例,P0.05。结论两性霉素B脂质体治疗侵袭性肺曲霉菌病的有效率及治愈率均高于伏立康唑,但肾功能损害发生率高于伏立康唑。
[Abstract]:Objective to compare the effects and adverse reactions of voriconazole and amphotericin B liposome in the treatment of invasive pulmonary aspergillosis. Methods 62 patients with suspected or confirmed invasive pulmonary aspergillosis were divided into 28 cases of voriconazole group and 34 cases of amphotericin B liposome group. The first day of the voriconazole group was given the load. The dose of voriconazole, 6 mg/kg, and 2 times /d, followed by a maintenance dose, 3 mg/kg, and 2 /d. amphotericin B liposome group treated with amphotericin B liposome, the initial dose and the maintenance dose were 0.3 mg/kg, and the 1 /d. had a definite etiological evidence for 4 mg/kg, 2 /d, and the dosage of amphotericin B group increased to 0.6 mg/kg, 1 times / 1. D. compared two groups of treatment effects and adverse reactions. Results the cure rate of the voriconazole group and amphotericin B group was 28.6%, 44.1%, and P0.05, respectively, the total effective rate was 42.8%, 58.8%, and the P0.05. voriconazole group did not have renal function damage during the period of drug use in the amphotericin B liposome group, 3 cases of amphotericin B liposomes were treated with the treatment of amphotericin B liposome. The effective rate and cure rate of invasive pulmonary aspergillosis were higher than that of voriconazole, but the incidence of renal impairment was higher than that of voriconazole.
【作者单位】：常熟市第二人民医院;
【分类号】：R519.8

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