IPAF与CTD-ILD临床特点

发布时间：2018-06-26 23:19

本文选题：CTD-ILD + IPAF　；参考：《南昌大学》2017年硕士论文

【摘要】：背景:结缔组织病(connective tissue disease,CTD)主要是指是一系列累及结缔组织的疾病,分为狭义的结缔组织及广义的结缔组织,一般以狭义的结缔组织定义为主。主要包括:原发性干燥综合症等。IPAF为近年来提出新型概念,为介于ITP与CTD-ILD之间的病,具有特征性的临床特点,但无法诊断CTD,有学者认为,可能为CTD早期阶段,加上CTD-ILD发病率以及死亡率逐年上升,早期发现IPAF变得尤为重要。目的:通过分析结缔组织病相关性间质性肺病CTD-ILD与IPAF的临床表现、影像学、病理学、自身抗体等特点及治疗特征,探讨各自临床特征,便于以后相关疾病的诊疗。方法:以“CTD-ILD,IPAF、结缔组织病、间质性肺病、SSc、SLE、NSIP“等关键词进行检索,找出关于CTD-ILD、IPA等方面的相关研究,从临床表现、影像学、病理学、自身抗体、治疗等方面进行分析,最后总结。结果与结论:IPAF为一类具有CTD-ILD疾病特征,根据国内外研究分析,及临床分析,我们发现在一些诊断为特发性肺间质纤维化的患者中,并非单纯的ITP,在很多方面具有ITP没有的特征,但是又无法诊断为风湿免疫性疾病。并且认识到它介于特发性间质性肺病与结缔组织疾病相关间质性肺病中间,可能为CTD前期,可能较CTD-ILD进展慢,可能预后较好,需要我们更多的探索。
[Abstract]:Background: connective tissue disease (connective tissue) is a series of diseases involving connective tissue, which is divided into narrow sense connective tissue and broad sense connective tissue. IPAF is a new concept proposed in recent years, which is a disease between ITP and CTD-ILD. It has characteristic clinical characteristics, but it can not diagnose CTD. Some scholars believe that it may be the early stage of CTD. Combined with the increasing incidence and mortality of CTD-ILD, early detection of IPAF becomes particularly important. Objective: to investigate the clinical features of CTD-ILD and IPAF in the diagnosis and treatment of connective tissue disease related interstitial pulmonary disease (CTD-ILD). Methods: by using the keywords of "CTD-ILDU IPAF, connective tissue disease, interstitial pulmonary disease SLESLENSIP", the relevant research on CTD-ILDNP-IPA was found, and the clinical manifestation, imaging, pathology, autoantibody and treatment were analyzed and summarized. Results and conclusion: IPAF is a kind of CTD-ILD disease. According to domestic and foreign studies and clinical analysis, we found that in some patients diagnosed as idiopathic pulmonary interstitial fibrosis, it is not a simple ITP.It has the characteristics that ITP does not exist in many aspects. But it is impossible to diagnose rheumatic immune disease. It is also recognized that it is between idiopathic interstitial pulmonary disease and connective tissue disease related interstitial pulmonary disease, which may be preCTD, may progress slower than CTD-ILD, may have a better prognosis, and needs more exploration.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R593.2;R563

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