血清肌抑素水平变化与慢性阻塞性肺疾病稳定期患者营养不良的关系研究

发布时间：2018-06-28 07:12

  本文选题：营养不良 + 肺疾病　； 参考：《中国现代医学杂志》2014年17期

【摘要】：目的观察慢性阻塞性肺疾病(COPD)患者外周血中血清肌抑素水平的变化,探讨肌抑素与COPD患者营养不良的关系。方法选取COPD稳定期住院患者76例及健康对照者80例,通过营养不良参数评分(MNI)对所有受试者进行营养状况评价,并采取酶联免疫吸附法检测各组受试者血清中的肌抑素及肿瘤坏死因子-α(TNF-α)水平。结果 COPD组患者的MNI分值高于健康对照组,差异均有统计学意义(P0.01)。其中COPD组MNI分值≥5分者占81.6%(62/76),MNI分值5分者仅占18.4%(14/76)。COPD组患者的肌抑素及TNF-α水平均显著高于健康对照组(P0.05)。COPD组患者血清肌抑素水平与MNI评分及TNF-α水平呈正相关(r=0.425,P=0.015;r=0.484,P=0.03)。结论多数COPD患者存在营养不良,其体内血清肌抑素水平较同龄健康人明显升高,肌抑素与COPD营养不良的发生关系密切。
[Abstract]:Objective to observe the changes of serum myostatin levels in patients with chronic obstructive pulmonary disease (COPD) and to explore the relationship between myostatin and malnutrition in COPD patients. Methods 76 inpatients with stable COPD and 80 healthy controls were selected to evaluate the nutritional status of all subjects by means of malnutrition parameter score (MNI). The serum levels of myostatin and tumor necrosis factor- 伪 (TNF- 伪) were detected by enzyme linked immunosorbent assay (Elisa). Results the MNI scores in COPD group were significantly higher than those in healthy control group (P 0.01). Among them, 81.6% (62 / 76) with MNI score 鈮，

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