胸腔积液中葡萄糖转运蛋白-1和生存蛋白表达在鉴别诊断肺腺癌、恶性间皮瘤和反应性间皮细胞增生中的意义

发布时间：2018-06-28 07:54

  本文选题：腺癌 + 间皮瘤　； 参考：《中国老年学杂志》2017年14期

【摘要】：目的探讨葡萄糖转运蛋白(GLUT)-1和生存蛋白(Survivin)表达在诊断肺腺癌、恶性间皮瘤及反应性间皮细胞增生患者胸腔积液中的临床意义。方法用免疫组化法检测肺腺癌、恶性间皮瘤、反应性间皮细胞增生各30例胸水沉渣组织中GLUT-1和Survivin的表达。结果肺腺癌、恶性间皮瘤、反应性间皮细胞增生的样本中GLUT-1阳性率分别为86.7%、83.3%、6.7%;而Survivin阳性率分别为80.0%、76.7%、30.0%。GLUT-1和Surivin在肺腺癌和恶性间皮瘤中染色弥漫性和染色强度方面无统计学差异(P0.05),但其与反应性间皮细胞增生的样本差异显著(P0.01)。结论 GLUT-I和Surivin可以将反应性间皮细胞增生从肺腺癌和恶性间皮瘤中鉴别出来,但是无法鉴别恶性间皮瘤和肺腺癌。
[Abstract]:Objective to investigate the clinical significance of glucose transporter (GLUT-1) and survivin (survivin) expression in pleural effusion in patients with lung adenocarcinoma, malignant mesothelioma and reactive mesothelioma. Methods the expressions of GLUT-1 and survivin in 30 cases of lung adenocarcinoma, 30 cases of malignant mesothelioma and 30 cases of reactive mesothelioma were detected by immunohistochemistry. Results Lung adenocarcinoma, malignant mesothelioma, The positive rates of GLUT-1 in reactive mesothelial cell proliferation samples were 86.7 and 83.3, respectively, while the positive rates of survivin were 80.0 and 76.70.0.GLUT-1 and Surivin were not significantly different in diffuse staining and staining intensity in lung adenocarcinoma and malignant mesothelioma (P0.05), but there was no significant difference between survivin and reactive mesothelioma (P0.05). The difference of cell proliferation samples was significant (P0.01). Conclusion GLUT-I and Surivin can differentiate reactive mesothelial cell proliferation from lung adenocarcinoma and malignant mesothelioma, but can not differentiate malignant mesothelioma from lung adenocarcinoma.
【作者单位】： 桂林医学院附属医院病理科;
【基金】：广西医疗卫生适宜技术开发与推广应用项目(No.S201601) 桂林市科学研究与技术开发计划项目(No.2016012706-8) 广西区卫计委自筹经费科研课题(No.Z2015414)
【分类号】：R561.3;R734
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本文编号：2077282