艾滋病和非艾滋病患者并发肺隐球菌病的临床特点对照分析

发布时间：2018-06-28 16:54

本文选题：艾滋病 + 隐球菌　；参考：《实用医学杂志》2014年22期

【摘要】：目的:探讨艾滋病(AIDS)患者与非艾滋病患者并发肺隐球菌病(PC)的临床特点及治疗转归。方法 :采用回顾性分析临床确诊的艾滋病与非艾滋病并PC患者的临床资料包括实验室指标及病理资料。结果:AIDS并发PC组全身症状较非AIDS组多(P0.05);两组呼吸系统症状差异无统计学意义(P0.05)。实验室检查结果示AIDS组CD3+T淋巴细胞数和CD4+T细胞数显著低于非AIDS组(P0.05)。AIDS组隐球菌荚膜多糖抗原检测阳性率明显低于非AIDS组(P0.05)。两组病理类型间比较差异无统计学意义(P0.05)。影像学检查示AIDS组更容易出现混合性病变,而非AIDS组则更容易出现结节影。经过治疗,恶化和死亡的患者在AIDS组有14例(33.3%),显著高于非AIDS组(3例,11.1%),差异有统计学意义(P0.05)。结论:AIDS并PC患者临床症状、影像学缺乏特异性表现,病理活检为主要确诊手段,转归过程中出现恶化、死亡的患者明显高于非AIDS患者。
[Abstract]:Objective: to investigate the clinical features and outcome of pulmonary cryptococcosis (PC) in AIDS patients and non-AIDS patients. Methods: the clinical data including laboratory data and pathological data were analyzed retrospectively. Results there were more systemic symptoms in PC group than in non-AIDS group (P0.05), and there was no significant difference in respiratory symptoms between the two groups (P0.05). Laboratory results showed that the number of CD3 T lymphocytes and CD4 T cells in AIDS group was significantly lower than that in non-AIDS group (P0.05). The positive rate of Cryptococcus capsular polysaccharide antigen detection in AIDS group was significantly lower than that in non-AIDS group (P0.05). There was no significant difference in pathological types between the two groups (P0.05). Imaging examination showed that mixed lesions were more likely in AIDS group and nodule shadow was more common in non-AIDS group. After treatment, there were 14 cases (33.3%) in AIDS group, which was significantly higher than that in non-AIDS group (3 cases, 11.1%), the difference was statistically significant (P0.05). Conclusion the clinical symptoms and imaging features of patients with AIDS and PC are not specific. Pathological biopsy is the main method of diagnosis, and the mortality of patients with AIDS is significantly higher than that of non-AIDS patients.
【作者单位】：广州市第八人民医院;川北医学院附属医院呼吸科;
【基金】：广东省医学科研基金立项课题(编号:A2014572)
【分类号】：R512.91;R519.4

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