联合检测降钙素原与高敏C反应蛋白在卒中相关性肺炎中的诊断和预测价值

发布时间：2018-06-30 01:36

本文选题：降钙素 + 血液　；参考：《福建医科大学学报》2015年01期

【摘要】：目的探讨脑卒中患者外周血降钙素原(PCT)、高敏C反应蛋白(hs-CRP)水平变化与卒中相关性肺炎(SAP)的相关性。方法连续纳入神经内科脑卒中患者106例,动态测定血PCT及hs-CRP变化,75例确诊为SAP的患者,根据PSI评分分为重症SAP组和轻症SAP组,并与非SAP组、对照组进行比较分析。结果重症SAP组、轻症SAP组血清PCT及hs-CRP浓度明显高于非SAP组,差别有统计学意义[PCT:(6.3±3.2)vs(0.5±0.1)μg/L,(5.6±1.3)vs(0.5±0.1)μg/L;hs-CRP:(28.5±7.2)vs(4.6±1.3)mg/L,(10.6±2.3)vs(4.6±1.3)mg/L,均为P0.05),且重症SAP组血清PCT及hs-CRP浓度和持续时间明显高于轻症SAP组(P0.05)。第5,7d血清PCT水平与PSI评分呈正相关,第3,5,7d血清hs-CRP水平与PSI评分呈正相关。以血清PCT(3.5μg/L)、hs-CRP(8.1mg/L)为界,诊断SAP的灵敏度分别为94%,91%,特异度分别为90%,75%。结论联合检测血清PCT和hs-CRP可作为SAP的早期诊断及治疗预后的指标。
[Abstract]:Objective to investigate the relationship between the levels of procalcitonin (PCT), Gao Min C-reactive protein (hs-CRP) and stroke associated pneumonia (SAP) in patients with stroke. Methods one hundred and sixty six patients with stroke in neurology department were enrolled in this study. 75 patients were diagnosed as SAP by dynamic determination of serum PCT and hs-CRP. According to PSI score, they were divided into severe SAP group and mild SAP group, and compared with non-SAP group and control group. Results the levels of serum PCT and hs-CRP in patients with severe SAP and mild SAP were significantly higher than those in non-SAP group (P 0.05). The levels of serum PCT and hs-CRP were significantly higher in severe SAP group than in non-SAP group [(6.3 卤3.2) vs (卤0.1) 渭 g / L, (5.6 卤1.3) vs (卤0.5 卤0.1) 渭 g / L, (28.5 卤7.2) vs (4.6 卤1.3) mg / L, (10.6 卤2.3) vs (vs 4.6 卤1.3) mg / L, respectively, P 0.05], and the levels and duration of serum PCT and hs-CRP in severe SAP group were significantly higher than those in mild SAP group (P0.05). The level of serum PCT was positively correlated with the PSI score on the 5th day and the hs-CRP level was positively correlated with the PSI score on the 3rd day of the 5th day. Using serum PCT (3.5 渭 g / L) and hs-CRP (8.1 mg / L) as the limit, the sensitivity of diagnosis of SAP was 9491 and the specificity was 90 and 755.The results showed that the sensitivity of serum PCT (3.5 渭 g / L) and the specificity of SAP were 90 mg / L and 90 渭 g / L, respectively. Conclusion combined detection of serum PCT and hs-CRP can be used as an early diagnosis and prognostic index of SAP.
【作者单位】：福建医科大学省立临床医学院福建省立医院神经内科;
【分类号】：R563.1;R743.3

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