类固醇激素联合β2受体激动剂对哮喘-慢性阻塞性肺疾病重叠综合征的短期疗效

发布时间：2018-07-03 11:39

本文选题：哮喘-慢性阻塞性肺疾病重叠综合征 + 慢性阻塞性肺疾病　；参考：《实用医学杂志》2017年15期

【摘要】：目的观察糖皮质激素(ICS)联合长效β2受体激动剂(LABA)吸入治疗哮喘-慢性阻塞性肺疾病重叠综合征(ACOS)的短期疗效。方法收集2012年3月至2015年3月期间来我院诊治后病情稳定的ACOS及慢性阻塞性肺疾病(COPD)患者即ACOS组、COPD组。完善肺功能检查、胸片、血嗜酸性粒细胞计数及生活质量(m MRC)评分,符合纳入标准的ACOS组(36例)和COPD组(88例)规律使用ICS联合LABA吸入治疗,3个月后复查以上指标。结果 ICS联合LABA吸入治疗3个月后,ACOS组及COPD组肺功能指标(FEV1、FVC、TLC、RV、IC、DLco)及m MRC均得到改善。ACOS组第1秒用力呼气容积(FEV1)指标改善较COPD组明显(P0.05),尤其是在轻至中度气流受限的患者中两组FEV1改变更为明显[(250.2±42.9)vs.(63.1±25.3)mL,P=0.003],在重度至极重度组治疗后两组FEV1的改善无统计学意义。结论 ICS联合LABA吸入治疗ACOS患者较COPD患者有明显的疗效,轻-中度ACOS患者治疗后肺功能改善更为明显。
[Abstract]:Objective to observe the short-term efficacy of inhaled glucocorticoid (ICS) combined with long-acting 尾 _ 2 agonist (LABA) in the treatment of asthmatic chronic obstructive pulmonary disease overlap syndrome (ACOS). Methods from March 2012 to March 2015, the patients with ACOS and chronic obstructive pulmonary disease (COPD) who had stable condition after treatment in our hospital, namely ACOS group and COPD group, were collected. Lung function examination, chest radiography, eosinophilic granulocyte count and quality of life (mMRC) score were improved. The results showed that 36 cases of ACOS group and 88 cases of COPD group were treated with ICS combined with LABA inhalation regularly, and the above indexes were reexamined 3 months later. Results the pulmonary function indexes (FEV _ 1 FV _ C _ (TLCV) TLCV _ (1) ICD _ (Dco) and m MRC in the ACOS group and COPD group were improved after 3 months of inhalation therapy. The improvement of forced expiratory volume (FEV _ 1) in the ACOS group was significantly higher than that in the COPD group (P0.05), especially in the mild to moderate airflow limitation group (P0.05), and the improvement of forced expiratory volume (FEV1) in the ACOS group was significantly higher than that in the COPD group (P0.05). The change of FEV1 was more obvious in the two groups [(250.2 卤42.9) vs. (63.1 卤25.3) mLP0. 003], but there was no significant difference between the two groups after treatment. Conclusion ICS combined with LABA inhalation is more effective than COPD in the treatment of ACOS, and the improvement of pulmonary function in mild to moderate ACOS patients is more obvious after treatment.
【作者单位】：新疆医科大学第一附属医院;
【分类号】：R562.25;R563.9

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