幽门螺杆菌感染与慢性阻塞性肺疾病的相关性

发布时间：2018-08-07 17:25

【摘要】：目的分析幽门螺杆菌(Hp)感染与慢性阻塞性肺疾病(COPD)的相关性,并探讨Hp感染对COPD患者肺功能的影响及血气分析的情况。方法 (1)回顾性分析住院的305例COPD患者为研究组,另选取305例健康体检者为对照组,将两组对象进行14C尿素呼气试验,比较两组Hp阳性率;(2)从305例COPD患者抽取140例Hp阳性和140例Hp阴性的COPD患者,比较两组的肺功能和血气分析的情况。结果 (1)研究组的Hp阳性率为66.8%,对照组为47.3%,两组比较差异有统计学意义(P0.01)。(2)肺功能检测结果示Hp阳性的COPD患者的FEV_1/FVC和FEV_1%pre水平高于阴性组;血气分析结果显示Hp阳性COPD组的PaO_2和SaO_2水平低于阴性的COPD患者,而PaCO_2的水平高于Hp阴性的COPD患者(均P0.01)。结论 COPD患者感染率比健康人群高,Hp感染与COPD关系密切,可能是COPD患者肺功能恶化的重要致病因素。
[Abstract]:Objective to analyze the relationship between Helicobacter pylori (Hp) infection and chronic obstructive pulmonary disease (COPD), and to explore the effect of HP infection on pulmonary function and blood gas analysis in COPD patients. Methods (1) A retrospective analysis of 305 COPD patients as study group and 305 healthy persons as control group was performed. The 14C urea breath test was performed in both groups. (2) 140 cases of HP positive and 140 cases of HP negative COPD were collected from 305 patients with COPD, and the pulmonary function and blood gas analysis were compared between the two groups. Results (1) the positive rate of HP was 66.8 in the study group and 47.3 in the control group. There was a statistically significant difference between the two groups (P0.01). (2). The results of pulmonary function test showed that the FEV_1/FVC and FEV_1%pre levels of the patients with HP positive COPD were higher than those of the negative group. Blood gas analysis showed that the levels of PaO_2 and SaO_2 in HP positive COPD group were lower than those in HP negative COPD group, while PaCO_2 level was higher in HP negative COPD group than in HP negative COPD group (all P0.01). Conclusion the infection rate of HP in patients with COPD is higher than that in healthy people. HP infection is closely related to COPD and may be an important pathogenic factor for the deterioration of pulmonary function in patients with COPD.
【作者单位】：广东省潮州市人民医院呼吸内科;
【分类号】：R563.9

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