CRP联合PCT对老年感染性肺炎患者临床早期诊断价值研究

发布时间：2018-08-07 20:06

【摘要】：目的探讨降钙素原(PCT)和C-反应蛋白(CRP)在老年患者感染性肺炎中的变化,以及CRP联合PCT在临床诊断中的价值。方法选取2012年9月-2016年9月180例医院收治的老年患者临床资料,按照有无肺炎分为两组,其中肺炎组90例,无肺炎组90例,检测两组患者PCT和CRP,比较两组入院后第1、7、10天血清PCT、CRP的动态变化,将肺炎组根据治疗方法随机分为常规治疗组和PCT联合CRP指导治疗组,观察PCT联合CRP指导治疗效果。结果两组患者CRP水平随着住院时程下降,住院第1、7天时,两组CRP及PCT水平差异有统计学意义(P0.05),住院第10天时,两组CRP及PCT水平差异无统计学意义;肺炎组中常规治疗和PCT联合CRP指导治疗患者抗菌药物疗程、住院费用比较,差异有统计学意义(P0.05),抗菌药物使用时间及住院费用少于常规治疗患者,住院时间无明显差异,不同治疗方法的治疗效果无明显差异。结论 CRP联合PCT能早期诊断老年感染性肺炎,且动态反映肺炎进展情况,可以指导临床治疗。
[Abstract]:Objective to investigate the changes of procalcitonin (PCT) and C-reactive protein (CRP) in the elderly patients with infectious pneumonia and the value of CRP combined with PCT in clinical diagnosis. Methods 180 elderly patients admitted from September 2012 to September 2016 were divided into two groups according to whether they had pneumonia, including 90 cases in pneumonia group, 90 cases in non-pneumonia group, 90 cases in pneumonia group and 90 cases in non-pneumonia group. PCT and CRP were detected in two groups, and the dynamic changes of serum PCTV-CRP were compared between the two groups on the 1st day after admission. The pneumonia group was randomly divided into routine treatment group and PCT combined with CRP guidance treatment group according to the treatment method. The therapeutic effect of PCT combined with CRP guidance was observed. Results the CRP level of the two groups decreased with the duration of hospitalization. The CRP and PCT levels of the two groups were significantly different at the 1st day of hospitalization (P0.05), but on the 10th day of hospitalization, there was no significant difference in CRP and PCT levels between the two groups. In the pneumonia group, there were significant differences in the course of antibiotics treatment and the hospitalization cost between the patients treated with routine therapy and PCT combined with CRP (P0.05). The duration of use of antibiotics and the cost of hospitalization were less than those of the patients treated with routine therapy, and there was no significant difference in hospitalization time. There was no significant difference in the effect of different treatment methods. Conclusion CRP combined with PCT can early diagnose senile infectious pneumonia and dynamically reflect the progress of pneumonia, and can guide clinical treatment.
【作者单位】：攀枝花市第二人民医院呼吸科;
【分类号】：R563.1

【参考文献】