碳酸酐酶Ⅻ在恶性和结核性胸腔积液鉴别诊断中的临床意义和可靠性

发布时间：2018-08-11 17:54

【摘要】：目的：本研究的目的是评估胸腔积液CAXII定量检测的临床应用价值。材料与方法：前瞻性收集50例淋巴细胞性胸腔积液进行研究，并通过ELISA方法定量分析胸水样本中CAXII的浓度。结果：与结核对照组（n=20）相比，胸腔积液CAXII的浓度在肺癌患者（n=30）中显著增高。这种生物标志物检测的敏感性和特异性分别为60％和75％。对于肺癌的诊断和排除，胸腔积液CAXII的检测不逊色于胸腔积液细胞学检查（灵敏度分别为60％和57％，特异性分别为75％和100％；阳性预测值77％，阴性预测值54％）。在肺癌所致恶性胸腔积液但细胞学检查阴性者，其中有54％胸腔积液CAXII检测为阳性。结论：与结核性胸腔积液相比，肺癌患者胸腔积液中CAXII浓度显著升高。胸水CAXII检测可能会在未来对肺癌患者恶性胸腔积液的细胞学检查提供一个有价值的辅助诊断方法，尤其是当细胞学检查不确定时。
[Abstract]:AIM: To evaluate the clinical value of CAXII quantitative detection in pleural effusion. Materials and Methods: 50 cases of lymphocytic pleural effusion were prospectively collected and studied. The concentration of CAXII in pleural effusion samples was quantitatively analyzed by ELISA. Results: The concentration of CAXII in pleural effusion was higher than that in tuberculosis control group (n=20). The sensitivity and specificity of this biomarker were 60% and 75% respectively. For the diagnosis and exclusion of lung cancer, the detection of CAXII in pleural effusion was not inferior to that of cytology in pleural effusion (sensitivity 60% and 57%, specificity 75% and 100%, respectively); positive predictive value 77%, negative predictive value 100%. Conclusion: Compared with tuberculous pleural effusion, the concentration of CAXII in pleural effusion of lung cancer patients is significantly higher. The detection of CAXII in pleural effusion of lung cancer patients may be used for cytological examination of malignant pleural effusion of lung cancer patients in the future. It provides a valuable auxiliary diagnostic method, especially when cytological examination is uncertain.
【学位授予单位】：济南大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R561.3

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