孟鲁斯特联合布地奈德福莫特罗粉吸入剂治疗老年妇女哮喘的临床研究

发布时间：2018-08-13 17:57

【摘要】：目的:探讨布地奈德福莫特罗粉剂吸入联合应用白三烯受体拮抗剂孟鲁斯特钠治疗老年妇女支气管哮喘的临床效果。方法:将60例轻、中度老年妇女支气管哮喘患者随机分为观察组和对照组各30例,观察组应用布地奈德福莫特罗粉剂吸入治疗,160μg/4.5μg,早、晚各1次,每次1吸,同时联合应用孟鲁斯特钠10 mg,每日1次,睡前口服,时间3个月。对照组则单纯应用布地奈德福莫特罗粉剂吸入治疗,160μg/4.5μg,早、晚各1次,每次1吸,时间3个月。结果:观察组的临床疗效优于对照组。治疗后观察组咳嗽、气短、夜间及凌晨发作天数、无缓解药物应用天数均较对照组明显减少(P0.05);肺功能较对照组明显改善,FEV1、PEF占预计值百分比差异有统计学意义(P0.01);治疗后观察组较对照组呼出气NO检测下降更明显、血清EOS减少更多(P0.01)。结论:对于老年女性单纯应用布地奈德福莫特罗药物吸入可能不到位、不确切,在此基础上联合应用白三烯受体拮抗剂孟鲁斯特钠口服可使疗效更确切,哮喘症状控制更理想,肺功能改善更明显,可作老年妇女轻、中度支气管哮喘治疗的可靠选择。
[Abstract]:Objective: to investigate the clinical effect of inhaled budesonide formoterol combined with leukotriene receptor antagonist Rust sodium in the treatment of bronchial asthma in elderly women. Methods: 60 cases of mild and moderate aged women with bronchial asthma were randomly divided into two groups: the observation group (n = 30) and the control group (n = 30). In the observation group, 160 渭 g / 4.5 渭 g of budesonide formoterol powder was inhaled, 1 dose each time, one time in the morning and one in the evening. At the same time, 10 mg of Rust sodium, once daily, taken orally before bedtime, for 3 months. The control group was treated with budesonide formoterol powder inhalation alone, 160 渭 g / 4.5 渭 g, 1 time each time for 3 months. Results: the clinical effect of the observation group was better than that of the control group. After treatment, the observation group had cough, shortness of breath, nightly and early morning attack days, Compared with the control group, the days of non-remission drug use were significantly decreased (P0.05); the pulmonary function significantly improved compared with the control group (P0.01); after the treatment of observation group compared with the control group, the level of no decreased more significantly, and the serum EOS decreased more (P0.01). Conclusion: inhaling budesonide formoterol alone may not be in place or exact for elderly women. On this basis, oral administration of Rust sodium, a leukotriene receptor antagonist, may make the efficacy more accurate and asthma symptom control more satisfactory. The improvement of pulmonary function is more obvious and can be used as a reliable choice for the treatment of mild and moderate bronchial asthma in elderly women.
【作者单位】：吉林大学第一医院呼吸科;吉林大学第一医院放射线科;
【分类号】：R562.25

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