支气管激发试验中患者症状分析

发布时间：2018-08-13 16:00

【摘要】：目的了解Astograph法支气管激发试验过程中不良反应发生情况及影响因素。方法选择937例患者用日本产支气管激发试验仪(CHEST公司的Astograph),由自动雾化发生装置、连续呼吸阻力测定装置和计算机显示(或描记)装置,受试者平静呼吸连续吸入由低到高浓度的激发剂的同时,仪器可自动而连续描记受试者的呼吸阻力(Rrs)的变化,结果由计算机处理后在屏幕上显示并可输出。显示或输出的结果包括呼吸阻力(Rrs)曲线等多项指标。观察在支气管激发试验过程中患者不良反应的发生情况及相关因素。结果 937例接受支气管激发试验患者中,年龄4~79岁,男性345例,女性592例,出现不良反应者268例(28.6%),其中气短、咳嗽、咽痒、咽干、胸闷、恶心、心慌等分别为171例(63.8%)、119例(44.4%)、82例(30.6%)、52例(19.4%)、37例(13.8%)、8例(3%)、7例(2.6%)其中激发试验阳性组气短症状发生率明显高于激发试验阴性组(分别为67.2%,33.0%;χ2=5.458,P=0.08)。性别、年龄、病程对不良反应发生率无影响,气道反应性越高气短症状越明显。结论 Astograph法支气管激发试验过程中,一过性不良反应发生率较高,其中咳嗽、咽痒、气短症状最常见。其中气短因素对试验影响最大,激发试验阴性者咳嗽症状发生率最高(48%),其次为咽痒(37%)、气短(33%)。937例接受支气管激发试验患者中,总不良反应发生率为28.6%,说明Astograph法支气管激发试验是安全有效的。
[Abstract]:Objective to investigate the occurrence and influencing factors of adverse reactions in bronchial provocation test with Astograph method. Methods A total of 937 patients were selected to use the Japanese bronchus excitation test instrument (Astograph), of CHEST Company) by automatic atomizing device, continuous breathing resistance measurement device and computer display (or recording) device. At the same time, the apparatus can automatically and continuously record the changes of respiratory resistance (Rrs) of the subjects. The results are displayed on the screen and output by computer. The results show or output include respiratory resistance (Rrs) curve and other indicators. To observe the occurrence and related factors of adverse reactions in bronchial provocation test. Results among the 937 patients with bronchial provocation test, the age was 479 years old, 345 male, 592 female, 268 (28.6%) had adverse reactions, including shortness of breath, cough, pharynx itching, dry pharynx, chest tightness, nausea. There were 171 cases (63.8%), 119 cases (44.4%), 82 cases (30.6%), 52 cases (19.4%), 37 cases (13.8%), 8 cases (3%), 7 cases (2.6%). The incidence of shortness of breath in the positive group was significantly higher than that in the negative group (67.2%; 蠂 2 5.458 P 0.08, respectively). Gender, age and course of disease had no effect on the incidence of adverse reactions, and the higher the airway reactivity, the more obvious the symptoms of shortness of breath. Conclusion the incidence of transient adverse reactions in bronchial provocation test by Astograph method is high, among which cough, itching and shortness of breath are the most common symptoms. Among them, shortness of breath had the greatest effect on the test. The incidence of cough symptoms was the highest (48%) in those with negative provocation test, followed by pharyngeal itching (37%), shortness of breath (33%) .937 cases of bronchial provocation test. The incidence of total adverse reactions was 28. 6, indicating that the bronchial provocation test by Astograph was safe and effective.
【作者单位】：新疆医科大学第一附属医院肺功能科;
【分类号】：R562.2

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