支气管哮喘激发试验前后大小气道指标的变化

发布时间：2018-08-16 14:51

【摘要】：目的:观察支气管激发试验阳性的支气管哮喘患者大小气道指标的改变,并探讨FEV1、PEF指标与小气道下降率的相关性。方法:对行激发试验(BPT)为阳性70例支气管哮喘患者进行回顾性分析,根据基础肺功能MMEF分为A、B两组,A组为MMEF≥80%,B组MMEF80%。观察其大气道FEV1、PEF、FEF75%、FEF50%、MMEF在激发前后、治疗前后的变化及FEV1、PEF与小气道指标的相关性。结果:1.A、B两组在年龄(岁)、身高(cm)、体重(kg)方面的差异是无统计学意义,P0.05。2.PEF异常率明显高于FEV1、FEF75%、FEF50%、MMEF异常率。3.A组与B组比较,在激发前、激发后的FEV1%pre、PEF%pre、FEF75%pre、FEF50%pre的变化的差异有统计学意义,均明显高于B组,P0.001。4.A、B两组中大小气道指标下降率(FEV1下降率、PEF下降率、FEF75下降率、FEF50下降率、MMEF下降率)相互之间是有明显差异的(P0.05),小气道指标下降率明显高于大气道指标下降率。A、B两组FEV1下降率、PEF下降率、FEF75下降率、MMEF下降率、FEF50下降率相比较之间存在的差异是没有统计学意义(P0.05)。5.A、B两组FEF75%、FEF50%、MMEF下降率与FEV1下降率之间的差异有统计学意义(P0.05)。6.A组FEF75%、FEF50%、MMEF下降率分别与PEF下降率之间的差异无统计学意义(P0.05)。B组小气道指标FEF50%、MMEF下降率与PEF下降率之间的差异无统计学意义(P0.05),FEF75下降率与PEF下降率之间有显著差异(P0.05)。7.FEV1、PEF下降率与FEF75、FEF50、MMEF下降率呈正相关(P0.001)。但年龄(岁)与小气道指标FEF75%、FEF50%、MMEF下降率之间不存在相关性,无统计学意义(P0.05)。8.A、B两组经治疗后PEF、FEF75%、FEF50%、MMEF指标明显改善。结论:支气管哮喘患者小气道具有很高的敏感性,明显高于大气道。小气道功能异常的患者和小气道功能正常患者在年龄方面的差异是没有统计学意义的。小气道功能正常组与小气道功能异常组的哮喘患者各大小气道指标的下降率之间有明显差异,但两组比较差异无统计学意义。大小气道之间存在正相关。小气道功能异常对哮喘的临床上有很大的影响,所以监测小气道指标对早期诊断、及时预防哮喘及评估哮喘疗效有很重要的意义。
[Abstract]:AIM: To observe the changes of airway parameters in bronchial asthma patients with positive bronchial provocation test (BPT), and to explore the correlation between FEV1, PEF and the decrease rate of small airway. The changes of airway FEV1, PEF, FEF 75%, FEF 50% and the correlation between FEV1, PEF and small airway parameters were observed before and after stimulation. Results: 1. There was no significant difference in age (age), height (cm) and weight (kg) between group A and group B, P 0.05.2. The abnormal rate of PEF was significantly higher than that of FEV1, FEF 75%, FEF 50%, and abnormal rate of MMEF. Compared with group B, the changes of FEV1% pre, PEF% pre, FEF75% pre, FEF50% pre before and after stimulation were statistically significant, which were significantly higher than those of group B (P 0.001.4.A). There were significant differences in the decrease rates of airway parameters (FEV1, PEF, FEF75, FEF50, MMEF) between two groups (P 0.05). The decrease rate of FEV1, PEF, FEF75, MMEF and FEF50 in group B was significantly higher than that in group B (P There was no significant difference between the decrease rate of FEF, FEF 50%, MMEF and PEF in group B (P 0.05). There was no significant difference between the decrease rate of MMEF and the decrease rate of PEF (P 0.05). There was significant difference between the decrease rate of FEF 75 and the decrease rate of PEF (P 0.05). 7. FEV1, the decrease rate of PEF was positively correlated with the decrease rate of FEF 75, FEF 50 and MMEF (P 0.05). However, there was no significant correlation between age (age) and the decrease rate of small airway parameters (FEF 75%, FEF 50%, MMEF). There was no statistical significance (P 0.05). PEF, FEF 75%, FEF 50% and MMEF were significantly improved in group B after treatment. There was no significant difference in age between patients with normal small airway function and asthmatic patients with abnormal small airway function. It is very important to monitor the small airway parameters for early diagnosis, timely prevention and evaluation of asthma.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R562.25

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