细胞免疫功能与老年细菌性肺炎及其严重程度的相关性

发布时间：2018-08-17 10:14

【摘要】：目的探讨细胞免疫功能与老年细菌性肺炎及其严重程度的相关性。方法选择70岁以上老年细菌性肺炎患者120例作为观察组,70岁以上老年健康体检者120例作为对照组,观察组根据肺炎严重程度分为重症肺炎组71例,非重症肺炎组49例。采用流式细胞仪分析细胞表面CD3~+、CD4~+、CD8~+阳性细胞率,CD4~+/CD8~+,自然杀伤细胞(NK)活性,采用酶联免疫吸附试验(ELISA)测定血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、IL-8水平。结果观察组CD8~+明显高于对照组(P0.05),CD4~+、CD4~+/CD8~+、NK活性明显低于对照组(P0.05),两组CD3~+无统计学差异(P0.05)。观察组血清TNF-α、IL-6、IL-8水平均明显高于对照组(P0.05)。重症肺炎组CD4~+、CD8~+、CD4~+/CD8~+、NK活性明显低于非重症肺炎组(P0.05),两组CD3~+无统计学差异(P0.05)。重症肺炎组血清TNF-α、IL-6、IL-8水平明显高于非重症肺炎组(P0.05)。结论老年细菌性肺炎患者存在细胞免疫功能异常,随着病情严重程度的增加,细胞免疫功能下降更显著。
[Abstract]:Objective to investigate the relationship between cellular immune function and the severity of bacterial pneumonia in the elderly. Methods 120 patients over 70 years old with bacterial pneumonia were selected as the control group. According to the severity of pneumonia, the observation group was divided into severe pneumonia group (71 cases) and non-severe pneumonia group (49 cases). The (NK) activity of natural killer cells was measured by flow cytometry. The levels of serum tumor necrosis factor (TNF)-伪 and interleukin (IL)-6 (IL-8) were measured by Elisa (ELISA). Results the activity of CD8 ~ + NK in the observation group was significantly higher than that in the control group (P0.05). The NK activity of CD4 ~ / CD4 ~ / CD8 ~ + in the observation group was significantly lower than that in the control group (P0.05), but there was no significant difference between the two groups (P0.05). The serum levels of TNF- 伪 IL-6 and IL-8 in the observation group were significantly higher than those in the control group (P0.05). The NK activity in severe pneumonia group was significantly lower than that in non-severe pneumonia group (P0.05), but there was no significant difference between the two groups (P0.05). The level of serum TNF- 伪 IL-6 + IL-8 in severe pneumonia group was significantly higher than that in non severe pneumonia group (P0.05). Conclusion there is abnormal cellular immune function in senile patients with bacterial pneumonia, and the decrease of cellular immune function is more significant with the increase of severity of the disease.
【作者单位】：浙江省立同德医院感染科;
【分类号】：R563.1

【相似文献】