COPD急性加重期和稳定期血清炎性因子水平及其与肺功能的关系

发布时间：2018-08-18 20:55

【摘要】：目的探讨COPD急性加重期和稳定期血清炎性因子水平变化及其与肺功能的关系。方法收集我院2010年3月—2013年9月呼吸内科确诊的COPD患者450例,依据其临床阶段分为急性加重期(207例)和稳定期(243例),并以本院体检科体检健康者100例为对照组,比较各组炎性因子水平、肺功能指标,肺功能分级与炎性因子的关系采用多分类Logistic回归分析。结果与对照组比较,稳定期COPD患者白介素(IL)-2降低,干扰素γ(IFN-γ)、结缔组织生长因子(CTGF)升高,急性加重期COPD患者IL-1β、IL-8、肿瘤坏死因子α(TNF-α)、IFN-γ、CTGF升高,IL-2降低(P0.05);与稳定期比较,急性加重期COPD患者IL-1β、IL-8、TNF-α、IFN-γ和CTGF升高,IL-2降低(P0.05)。稳定期和急性加重期COPD患者较对照组一秒用力呼气容积(FEV1)、FEV1/用力肺活量(FVC)和FEV1占预计的百分比值降低(P0.05);急性加重期较稳定期COPD患者FEV1、FEV1/FVC和FEV1占预计值的百分比降低(P0.05)。多分类Logistic回归分析结果显示,IL-1β、IL-2、IL-8、TNF-α、IFN-γ和CTGF与肺功能有回归关系(P0.05)。结论 IL-1β、IL-8、TNF-α、IFN-γ和CTGF升高是COPD急性加重的主要指标,对指导临床治疗COPD和其严重程度的判断有一定意义。
[Abstract]:Objective To investigate the changes of serum inflammatory factors and their relationship with pulmonary function in patients with acute exacerbation and stable stage of COPD.Methods 450 cases of COPD diagnosed in respiratory department of our hospital from March 2010 to September 2013 were collected and divided into acute exacerbation stage (207 cases) and stable stage (243 cases) according to their clinical stage. Results Compared with the control group, the levels of inflammatory factors, pulmonary function index, pulmonary function grade and the relationship between inflammatory factors were analyzed by multiple logistic regression. Necrosis factor alpha (TNF-alpha), IFN-gamma, CTGF increased, IL-2 decreased (P 0.05); Compared with the stable phase, the levels of IL-1 beta, IL-8, TNF-alpha, IFN-gamma and CTGF increased and IL-2 decreased (P 0.05) in patients with COPD in acute exacerbation and stable phase. The percentages of FEV1, FEV1/FVC and FEV1 in predicted values were lower in patients with COPD at acute exacerbation stage than those at stable stage (P 0.05). Multiple logistic regression analysis showed that IL-1 beta, IL-2, IL-8, TNF-a, IFN-gamma and CTGF were correlated with pulmonary function (P 0.05). Conclusion The elevation of IL-1 beta, IL-8, TNF-a, IFN-gamma and CTGF was the main index of acute exacerbation of COPD. It has a certain significance in guiding the clinical treatment of COPD and its severity.
【作者单位】：武汉理工大学医院内科;
【分类号】：R563.9

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