老年肺炎患者血浆超氧化物歧化酶水平与肺炎严重程度的相关性分析

发布时间：2018-08-19 06:13

【摘要】：目的探讨老年社区获得性肺炎(CAP)患者血浆超氧化物歧化酶(SOD)水平变化及与脓毒症、炎症指标的相关性,以期通过干预手段降低老年CAP患者的并发症及病死率。方法选择2013年1-10月住院确诊的141例老年CAP患者为肺炎组,同期选择90例非肺炎患者为对照组,分别测定两组患者血浆SOD、降钙素原(PCT)及C-反应蛋白(CRP)水平,依据脓毒症诊断标准将患者分为脓毒症组98例和非脓毒症组43例。结果肺炎组与对照组患者血浆SOD水平分别为(103.41±25.30)、(124.30±28.20)U/ml,两组比较差异有统计学意义(P0.05);脓毒症与非脓毒症组患者血浆SOD水平分别为(99.24±23.40)、(112.91±27.20)U/ml,两组之间比较差异有统计学意义(P0.05),PCT水平分别为(2.05±7.70)、(0.20±0.50)ng/ml,CRP水平分别为(76.05±70.00)、(33.39±43.50)mg/L,PCT和CRP在两组之间比较,差异均有统计学意义(P0.05);肺炎组血浆SOD水平与PCT、CRP呈负相关(r=-0.199、-0.232,P0.05)。结论老年CAP患者血浆SOD水平降低,并随炎症程度进展及合并脓毒症,下降更为显著,反映老年肺炎患者尤其合并脓毒症时抗自由基氧化能力减低。
[Abstract]:Objective To investigate the changes of plasma superoxide dismutase (SOD) levels in elderly patients with community-acquired pneumonia (CAP) and its correlation with sepsis and inflammation, so as to reduce the complications and mortality of elderly patients with CAP by intervention. Methods 141 elderly patients with CAP admitted from January to October 2013 were selected as pneumonia group, and 90 cases were selected at the same time. Non-pneumonia patients were divided into sepsis group (98 cases) and non-sepsis group (43 cases) according to the diagnostic criteria of sepsis. Results The levels of plasma SOD in pneumonia group and control group were (103.41 [25.30], (124.30 [28.20] U / ml, respectively. The levels of SOD in sepsis group and non-sepsis group were (99.24+23.40), (112.91+27.20) U/ml, and there was significant difference between the two groups (P 0.05). The levels of PCT were (2.05+7.70), (0.20+0.50) ng/ml, CRP were (76.05+70.00), (33.39+43.50) mg/L, PCT and CRP were (33.39+43.50) mg/L, respectively. Conclusion The level of SOD in elderly patients with CAP is lower than that in PCT and CRP (r=-0.199, -0.232, P 0.05). The decrease is more significant with the progress of inflammation and the complication of sepsis, which reflects the decrease of anti-free radical oxidation ability in elderly patients with pneumonia, especially with sepsis.
【作者单位】：首都医科大学附属北京世纪坛医院老年医学科;
【基金】：中国铁路总公司科技研究开发计划基金项目(2013Z003-C)
【分类号】：R563.1

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