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呼吸机相关性肺炎并发假丝酵母菌感染患者PCT、IL-6和CRP水平分析

发布时间:2018-09-03 13:40
【摘要】:目的探究呼吸机相关性肺炎(VAP)并发单一假丝酵母菌感染患者的临床特征以及与降钙素原(PCT)、白细胞介素-6(IL-6)和C-反应蛋白(CRP)等炎症指标的相关性。方法选择2008年1月-2016年3月医院收治的149例VAP患者,根据假丝酵母菌感染的相关诊断标准,分为假丝酵母菌属组65例、其他病菌组84例;比较两组患者临床指标。结果在65例伴有假丝酵母菌感染的VAP患者中,以白假丝酵母菌感染为主,共40株占61.54%;在假丝酵母菌属组中,β-葡聚糖阳性患者的PCT、IL-6以及CRP水平均显著高于β-葡聚糖阴性患者,组间比较差异有统计学意义(P0.05)。结论导致VAP患者发生的假丝酵母菌感染的易感因素众多,在临床治疗期间需积极消除各种易感因素,及时给予其相应的抗真菌感染治疗;β-葡聚糖在评价假丝酵母菌感染以及感染程度上具有一定的临床应用价值。
[Abstract]:Objective to investigate the clinical features of patients with ventilator-associated pneumonia (VAP) complicated with single Candida cerevisiae infection and its correlation with procalcitonin (PCT), interleukin-6 (IL-6) and C-reactive protein (CRP). Methods 149 patients with VAP from January 2008 to March 2016 were divided into Candida group (n = 65) and other bacteria group (n = 84) according to the diagnostic criteria of Candida infection. Results among 65 VAP patients with Candida cerevisiae infection, 40 strains were Candida albicans infection (61.54%), and the levels of PCT,IL-6 and CRP in Candida group were significantly higher than those in 尾 -glucan negative group. The difference between groups was statistically significant (P0.05). Conclusion there are many susceptible factors of Candida cerevisiae infection in patients with VAP. 尾-glucan has certain clinical value in evaluating Candida candida infection and the degree of infection.
【作者单位】: 南阳市第二人民医院呼吸内科;南阳医专一附院骨科;南阳医专一附院重症医学科;
【基金】:河南省科技攻关基金资助项目(971200100)
【分类号】:R563.1

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