二陈汤加味治疗慢性阻塞性肺疾病急性加重期（痰浊阻肺证）的临床观察

发布时间：2018-09-04 07:58

【摘要】：目的：观察二陈汤加味对COPD急性加重期(痰浊阻肺证)患者的临床症状及肺功能的影响,客观评估其临床疗效。方法：选取COPD急性加重期患者60例,西医严重程度分级为Ⅰ～Ⅲ级,同时中医辨证为痰浊阻肺证,以随机分配方式分成治疗组及对照组各30例。对照组给予单纯西医治疗,治疗组在常规西医治疗基础上联合二陈汤加味,疗程共为14天,观察患者治疗前后肺功能、临床症状、体征的变化。结果：1、二陈汤加味治疗COPD急性加重期(痰浊阻肺证)的患者可明显改善患者的临床症状,治疗组总有效率96.67%,对照组总有效率83.33%,两者比较有统计学意义(P0.05),治疗组的疗效优于对照组。治疗组在主症胸满、咳嗽、痰多、色白黏腻或呈泡沫、短气、喘息及兼次症脘痞、纳少、倦怠乏力等方面改善明显优于对照组,差异有统计学意义(P0.05)；两组在兼次症畏风易汗、泛恶、便溏方面的改善无明显差异(P0.05)。2、两组患者肺功能指标FEV1%pred、FEV1/FCV%较治疗前均有所改善(P0.05)；且治疗组在治疗后FEV1%pred、FEV1/FCV%改善方面优于对照组,有统计学意义(P0.05)。3、治疗后,两组患者血细胞分析、尿液常规分析、便常规、肝功能、肾功能、心电图等安全性指标无异常,且患者均未出现明显不适反应。结论：1、二陈汤加味可明显改善COPD急性加重期(痰浊阻肺证)患者的临床症状；2、二陈汤加味可改善COPD急性加重期(痰浊阻肺证)患者肺通气功能；3、二陈汤加味治疗COPD急性加重期(痰浊阻肺证)患者的治疗过程中无明显毒副作用及不良反应。
[Abstract]:Objective: to observe the effect of Erchen decoction on the clinical symptoms and pulmonary function of patients with acute exacerbation of COPD. Methods: 60 patients with acute exacerbation of COPD were divided into treatment group (n = 30) and control group (n = 30). The control group was treated with simple western medicine, and the treatment group was treated with Erchen decoction on the basis of routine western medicine. The course of treatment was 14 days. The changes of pulmonary function, clinical symptoms and signs were observed before and after treatment. Results the clinical symptoms of the patients with acute exacerbation of COPD (phlegm turbid obstruction of lung syndrome) could be improved obviously by adding Wei 1 and Erchen Tang. The total effective rate of the treatment group was 96.677.The total effective rate of the control group was 83.33.The comparison between the two groups was statistically significant (P0.05). The curative effect of the treatment group was better than that of the control group. The treatment group was significantly better than the control group in chest filling, cough, phlegm, color, white, sticky or foam, shortness of breath, wheezing and chronic epigastric distension, less intake and fatigue, etc. The difference was statistically significant (P0.05). There was no significant difference in the improvement of loose stools (P0.05). The pulmonary function index (FEV1%pred,FEV1/FCV%) was improved in the two groups (P0.05), and the improvement of FEV1%pred,FEV1/FCV% in the treatment group was better than that in the control group (P0.05) .3.After the treatment, the two groups had blood cell analysis. The routine analysis of urine showed that there were no abnormal safety indexes such as stool routine, liver function, renal function and electrocardiogram, and no obvious discomfort was found in the patients. Conclusion the clinical symptoms of patients with acute exacerbation of COPD (phlegm turbid obstruction of lung syndrome) can be obviously improved by adding Wei 1 and er Chen Tang, and the pulmonary ventilation function of patients with acute exacerbation of COPD (phlegm turbid obstruction of lung) can be improved by Erchen decoction. There were no obvious side effects and side effects during the treatment of acute exacerbation of COPD (phlegm turbid obstruction of lung syndrome).
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R563.9

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