布地奈德雾化吸入治疗对老年慢性阻塞性肺疾病急性加重期患者肺功能、降钙素原和C反应蛋白水平的影响

发布时间：2018-09-09 09:07

【摘要】：目的探讨布地奈德雾化吸入治疗老年慢性阻塞性肺疾病(COPD)急性加重期患者的疗效及对患者肺功能、降钙素原(PCT)和C反应蛋白(CRP)水平的影响。方法 230例老年COPD急性加重期患者随机数字表法分为布地奈德组(n=117)和对照组(n=113),两组均给予止咳、平喘、抗感染、低流量吸氧等常规治疗,在常规治疗的基础上对照组给予甲泼尼龙琥珀酸钠治疗,在对照组治疗的基础上给予布地奈德组布地奈德雾化吸入治疗,两组均治疗7 d,分别于治疗前后检测两组肺功能、PCT、CRP表达水平。结果治疗前两组1 s用力呼气容积(FEV1)、用力肺活量(FVC)比较差异无统计学意义(P0.05),治疗后布地奈德组均高于对照组(P0.05)。治疗前两组PCT、CRP水平比较差异无统计学意义(P0.05),治疗后布地奈德组均低于对照组(P0.05)。布地奈德组治疗总有效率高于对照组(P0.05)。治疗前两组生活质量综合评定问卷-74项(GQOL-74)总评分比较无统计学差异(P0.05),治疗后布地奈德组高于对照组(P0.05)。结论在常规治疗的基础上给予老年COPD急性加重期患者布地奈德雾化吸入治疗能够有效减轻患者体内炎性反应,改善患者肺功能,疗效确切,有利于提高患者生活质量。
[Abstract]:Objective to investigate the efficacy of budesonide atomization inhalation in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and its effects on pulmonary function and the levels of procalcitonin (PCT) and C-reactive protein (CRP). Methods two hundred and thirty elderly patients with acute exacerbation of COPD were randomly divided into budesonide group (n = 117) and control group (n = 113). On the basis of routine treatment, the control group was treated with methylprednisolone sodium succinate, while the control group was treated with budesonide atomized inhalation. Both groups were treated for 7 days, and the expression of PCT CRP was detected before and after treatment. Results there was no significant difference in forced expiratory volume (FEV1) and forced vital capacity (FVC) between the two groups before treatment (P0.05). After treatment, budesonide group was higher than control group (P0.05). There was no significant difference in PCT,CRP level between the two groups before treatment (P0.05). After treatment, budesonide group was lower than the control group (P0.05). The total effective rate of budesonide group was higher than that of control group (P0.05). Before treatment, there was no significant difference in the total score of GQOL-74 between the two groups (P0.05). After treatment, budesonide group was higher than the control group (P0.05). Conclusion on the basis of routine treatment, budesonide atomization inhalation in elderly patients with acute exacerbation of COPD can effectively reduce the inflammatory reaction and improve the pulmonary function of the patients. It is effective and beneficial to improve the quality of life of patients with acute exacerbation of COPD.
【作者单位】：新疆生产建设兵团第九师医院内二科;石河子大学第一附属医院呼吸一科;
【分类号】：R563.9

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