腹腔常频和高频喷射给氧对急性呼吸窘迫综合征家犬低血氧的改善效果

发布时间：2018-09-17 14:37

【摘要】：目的观察经腹腔常频喷射通气(CFJV)和高频喷射通气(HFJV)给氧对急性呼吸窘迫综合征(ARDS)家犬低血氧的改善效果。方法 15只家犬常规麻醉后在温盐水肺灌洗诱发ARDS模型后,将实验动物随机均分为三组,分别为对照组(C组)、CFJV组和HFJV组,并进行各组相应处理。观察三组建模前(T0)、建模时(T1)、建模后15min(T2)、30min(T3)、60min(T4)、90min(T5)、120min(T6)时动、静脉血氧分压、电解质、HR、MAP的变化。结果与T0时比较,T1时三组PaO2、PvO2明显降低、PaCO2明显升高(P0.05)。与C组比较,T2～T6时HFJV组、T2和T3时CFJV组PaO2明显升高(P0.05);T2～T4时HFJV组PaCO2和T3～T6时HFJV组和CFJV组PvO2明显升高(P0.05)。与CFJV组比较,T5、T6时HFJV组PaO2明显升高(P0.05)。三组电解质、HR、MAP差异均无统计学意义。结论腹腔CFJV和HFJV给氧对急性肺损伤家犬低血氧均有显著改善效果。
[Abstract]:Objective to observe the effect of (CFJV) and (HFJV) on the improvement of hypoxic oxygen in (ARDS) dogs with acute respiratory distress syndrome (ARDS). Methods Fifteen dogs were randomly divided into three groups: control group (group C) and HFJV group after ARDS model was induced by warm saline lung lavage after routine anesthesia. The changes of arterial and venous oxygen pressure and electrolyte HRMAP were observed before (T _ 0), (T _ 1) and (T _ 3) (T _ 3) ~ (60) min (T _ (4) ~ (90) min (T _ (5) ~ (120) min (T _ (6) after modeling. Results compared with T _ 0, PaO2,PvO2 in T _ 1 group was significantly lower than that in T _ 1 group (P 0.05). Compared with C group, PaO2 in CFJV group at T _ 2 T _ 6 and T _ 3 in HFJV group was significantly higher than that in C group (P0.05). PaCO2 in HFJV group and PvO2 in CFJV group in T _ 2 T _ 4 group were significantly higher than those in HFJV group (P 0.05). Compared with CFJV group, PaO2 in HFJV group was significantly higher than that in HFJV group (P 0.05). There was no significant difference in HRMAP among the three groups. Conclusion both CFJV and HFJV can significantly improve the blood hypoxia in dogs with acute lung injury.
【作者单位】：南京大学医学院附属鼓楼医院麻醉科;
【分类号】：R563.8

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