重度COPD患者血中肌肉抑制素与BMI、动脉氧分压及二氧化碳分压的关系

发布时间：2018-10-11 19:41

【摘要】：目的:研究稳定期重度慢性阻塞性肺病(COPD)患者中肌肉抑制素、动脉氧分压及二氧化碳分压的情况及相关性,并据BMI进行分层研究。方法:选择稳定期重度COPD男性患者为研究组及年龄相仿的中度COPD男性为对照组,肺功能仪器检测每位受试者的1 s用力呼气容积(FEV1)及其预计值;测定身高及体质量,计算BMI,用酶联免疫吸附法测定肌肉抑制素;抽动脉血进行血气分析。研究组与对照组比较,探讨肌肉抑制素与动脉氧分压及二氧化碳分压的相关性。结果:根据BMI分组的重度COPD组患者血清中肌肉抑制素及二氧化碳分压水平较对照组均有升高,而动脉氧分压明显下降;研究组中BMI低者肌肉抑制素及二氧化碳分压水平升高更明显,动脉氧分压下降更明显(P0.05)。BMI与肌肉抑制素呈负相关,FEV1/预计值与肌肉抑制素呈负相关;肌肉抑制素与二氧化碳分压呈正相关,与动脉氧分压呈负相关。结论:COPD患者肌肉抑制素水平越高,BMI越低,患者缺氧及二氧化碳储留更突出,病情越重,预后越差。肌肉抑制素在COPD疾病有重要作用,肌肉抑制素可能成为COPD患者的潜在治疗靶点。
[Abstract]:Aim: to study the relationship among muscle inhibin, partial pressure of oxygen and partial pressure of carbon dioxide in patients with (COPD). Methods: male patients with stable severe COPD were selected as study group and moderate COPD men of similar age as control group. The forced expiratory volume (FEV1) and its predicted value were measured by pulmonary function instrument, and their height and body mass were measured. BMI, was determined by enzyme-linked immunosorbent assay (Elisa) and arterial blood was collected for blood gas analysis. The relationship between muscle inhibin and partial arterial oxygen pressure and carbon dioxide partial pressure was studied in the study group and the control group. Results: the serum levels of muscle inhibin and partial pressure of carbon dioxide in severe COPD group were higher than those in control group, but the arterial partial pressure of oxygen decreased significantly. In the study group, the level of muscle inhibin and partial pressure of carbon dioxide increased significantly in patients with low BMI, and the decrease of arterial partial pressure of oxygen was more obvious (P0.05). BMI was negatively correlated with muscle inhibin, and the predicted value of FEV1/ was negatively correlated with muscle inhibin. Muscle inhibin was positively correlated with partial pressure of carbon dioxide and negatively correlated with partial pressure of arterial oxygen. Conclusion: the higher the level of muscle inhibin and the lower the level of BMI in patients with COPD, the more prominent hypoxia and carbon dioxide storage are, the more serious the condition is, the worse the prognosis is. Myostatin plays an important role in COPD disease and may be a potential therapeutic target for COPD patients.
【作者单位】：重庆市第三人民医院呼吸内科;重庆市江津中心医院;重庆医科大学第二临床学院呼吸内科;
【基金】：重庆市科委资助项目(cstc2013jcyjA1062)~~
【分类号】：R563.9

【相似文献】