太原市大气PM2.5对哮喘患者炎症因子的影响

发布时间：2018-10-12 08:00

【摘要】：目的探讨大气PM2.5对哮喘患者炎症因子的影响,寻找用于评价PM2.5污染效应的敏感指标,为阐明PM2.5加重哮喘发生的机制提供参考。方法选择太原市迎泽区社区哮喘患者19名,分别于2012年12月和2013年6月对患者进行7 d的大气PM2.5暴露监测,并于监测最后一天采集血样进行炎症因子检测,比较两阶段哮喘患者的PM2.5暴露差别及体内相关炎症因子[白介素-8(IL-8)、白介素-13(IL-13)、γ干扰素(IFN-γ)]的变化情况。结果哮喘患者冬季室外、室内大气PM2.5暴露日均浓度和个体PM2.5暴露日均浓度均高于夏季;冬季血浆炎症因子IL-13浓度高于夏季,IFN-γ浓度低于夏季,差异均有统计学意义(P0.05)。哮喘患者个体PM2.5暴露浓度与室外、室内PM2.5暴露浓度呈正相关(r值分别为0.809,0.826,P0.05),室外PM2.5暴露浓度与室内PM2.5暴露浓度呈正相关(r=0.769,P0.05)。哮喘患者血浆IL-8浓度与个体PM2.5暴露浓度呈正相关(r=0.498,P0.05);血浆IL-13与室外PM2.5暴露浓度呈正相关(r=0.579,P0.05),与IFN-γ浓度呈负相关(r=-0.536,P0.05)。结论外周血中炎症因子IL-13、IFN-γ可能是大气PM2.5加重哮喘的敏感指标。
[Abstract]:Objective to investigate the effect of atmospheric PM2.5 on inflammatory factors in asthmatic patients, and to find a sensitive index to evaluate the effect of PM2.5 pollution, and to provide a reference for elucidating the mechanism of PM2.5 exacerbating asthma. Methods A total of 19 asthmatic patients in Yingze District of Taiyuan City were selected and monitored for atmospheric PM2.5 exposure for 7 days in December 2012 and June 2013, respectively. Blood samples were collected on the last day of monitoring for the detection of inflammatory factors. To compare the difference of PM2.5 exposure and the changes of interleukin-8 (IL-8), interleukin-13 (IL-13), interferon 纬 (IFN- 纬) in patients with two-stage asthma. Results the daily average concentrations of indoor PM2.5 exposure and individual PM2.5 exposure in winter were higher than those in summer, and the concentrations of plasma inflammatory factor IL-13 and IFN- 纬 in winter were higher than those in summer, and the differences were statistically significant (P0.05). There was a positive correlation between the concentration of PM2.5 exposure and outdoor PM2.5 exposure (r = 0.809 卤0.826), and between outdoor PM2.5 exposure concentration and indoor PM2.5 exposure concentration (r = 0.809 卤0.826) (r = 0.769P 0.05). There was a positive correlation between plasma IL-8 concentration and individual PM2.5 exposure (P 0.05), a positive correlation between plasma IL-13 and outdoor PM2.5 exposure (P 0.05), and a negative correlation between IL-13 concentration and IFN- 纬 concentration (P 0.05). Conclusion the inflammatory factor IL-13,IFN- 纬 in peripheral blood may be a sensitive index for the exacerbation of asthma by atmospheric PM2.5.
【作者单位】：山西医科大学公共卫生学院环境卫生学教研室;
【基金】：教育部留学回国人员科研启动基金(2013-1792) 山西省回国留学人员科研资助项目(2013-057) 山西省高校优秀青年学术带头人支持项目(晋教科2009-6)
【分类号】：R122;R562.25

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