感染诱发的ARDS预后危险因素分析
发布时间:2018-10-26 19:08
【摘要】:目的:通过对感染诱发的ARDS患者的临床资料分析,探讨影响病情发展及预后的相关因素,为预测和干预感染诱发的ARDS患者预后提供理论依据,以期降低死亡率,提高救治率。 方法:回顾性分析2010年3月到2012年12月宁夏医科大学总医院ICU科收治的由感染诱发的ARDS共52例患者的临床资料,根据预后将其分为存活组(n=27)和死亡组(n=25)。分别统计两组患者的年龄、性别、合并的慢性基础疾病、急性器官功能障碍的个数及种类、APACHEⅡ评分、血气指标、其他生化指标、病原学培养的种类及其耐药性、广谱抗生素使用的种类等临床资料,并分析与患者预后的关系。统计学分析使用SPSS17.0软件进行分析,计量资料两组间比较采用独立样本的t检验,计数资料采用x2检验,多因素分析采用条件Logistic回归方法。 结果:①单因素分析显示合并慢性脏器疾病(P=0.036)、起始病因肺内感染(P=0.011)、急性心血管系统功能障碍(P=0.015)、急性胃肠道功能障碍(P=0.038)、血尿素氮(P=0.032)、白蛋白(P=0.028)、并发白色念珠菌感染(P=0.023)等因素在存活组和死亡组有统计学差异;②多因素分析显示:起始病因肺内感染(P=0.016,OR:2.203,OR95%CI:1.156-4.201)急性心血管系统功能障碍(P=0.010,OR:1.149,OR95%CI:1.034-1.278)、并发白色念珠菌感染(P=0.046,OR:0.994,OR95%CI:0.988-1.000)在存活组和死亡组中具有统计学差异,其余各因素在两组中均无明显差异。③52例患者入住ICU期间各类标本培养出病原菌110株,前5位分别为鲍曼不动杆菌(19.1%),白色念珠菌(11.9%),铜绿假单胞菌(10.9%),大肠埃希菌(10.0%)肺炎克雷伯菌(8.2%)。 结论:1、影响感染诱发ARDS的预后危险因素有:起始病因为肺内感染、合并慢性脏器疾病、急性心血管系统功能障碍、尿素氮水平升高、白蛋白水平的降低、并发白色念珠菌感染。2、起始病因肺内感染、急性心血管系统功能障碍、并发白色念珠菌感染是影响ARDS预后的独立危险因素。
[Abstract]:Objective: to analyze the clinical data of ARDS patients induced by infection, and to explore the related factors influencing the development and prognosis of ARDS, to provide theoretical basis for predicting and intervening the prognosis of ARDS patients induced by infection, in order to reduce the mortality rate and improve the treatment rate. Methods: the clinical data of 52 patients with infectious ARDS admitted in ICU Department of Ningxia Medical University General Hospital from March 2010 to December 2012 were retrospectively analyzed. According to the prognosis, they were divided into survival group (nong27) and death group (nong25). Age, sex, number and type of acute organ dysfunction, APACHE 鈪,
本文编号:2296680
[Abstract]:Objective: to analyze the clinical data of ARDS patients induced by infection, and to explore the related factors influencing the development and prognosis of ARDS, to provide theoretical basis for predicting and intervening the prognosis of ARDS patients induced by infection, in order to reduce the mortality rate and improve the treatment rate. Methods: the clinical data of 52 patients with infectious ARDS admitted in ICU Department of Ningxia Medical University General Hospital from March 2010 to December 2012 were retrospectively analyzed. According to the prognosis, they were divided into survival group (nong27) and death group (nong25). Age, sex, number and type of acute organ dysfunction, APACHE 鈪,
本文编号:2296680
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