2010-2015年武汉及周边地区发热呼吸道感染病毒病原学研究

发布时间：2018-10-26 22:00

【摘要】：本研究收集武汉及周边地区2010年1月到2015年12月的发热呼吸道样本,通过PCR等方法检测了流感病毒,呼吸道合胞病毒,副流感病毒,人腺病毒,人冠状病毒,人博卡病毒,人偏肺病毒和人鼻病毒等八种常见的发热呼吸道病毒。我们于2010-2015年间在武汉市及其周边地区总共收集5387份标本,任意病毒阳性的检出率为67.4%。八种病原的检出率依次为流感病毒(32.9%),呼吸道合胞病毒(14.1%),人腺病毒(14.0%),副流感病毒(10.7%),人冠状病毒(10.7%),人鼻病毒(4.1%),人偏肺病毒(2.1%)和人博卡病毒(1.4%)。总体来看,任意病毒感染在性别上的分布并不具有统计学差异。但是流感病毒,人冠状病毒和人鼻病毒感染在性别上的分布具有统计学差异。患者年龄在0岁到89.2岁之间,中位数年龄为2.0岁。进一步将患者按年龄分为八个不同的年龄组(0-5,6-11,12-23,24-35,36-47,48-59,60-71 和 72 岁以上),检测样本数分别为3836,443,309,338,203,165,63和30人份。各个年龄组的任意一种病毒检出率都在58%以上,流感病毒病毒在12-36岁的人群中和72岁以上的老人中检出率较高;呼吸道合胞病毒病毒和副流感病毒病毒在6-11岁青少年的检出率最高,其次是0-5岁的儿童,在60岁以上的老人中也有较高的检出率;人腺病毒病毒和人冠状病毒病毒在0-5年龄组的检出率最高,其次是6-11岁的青少年,在60岁以上的老人中也有较高的检出率;人偏肺病毒病毒检出率较高的年龄组是0-5岁的儿童,36-47岁成人和72以上的老人;人博卡病毒和人鼻病毒病毒在0-5岁的儿童中检出率最高。部分发热呼吸道病毒感染呈现一定的季节性特征,流感病毒感染主要发生在每年春季和秋季;呼吸道合胞病毒感染则主要集中在每年的冬季和春季;副流感病毒感染则主要集中在每年的冬季和夏季;人腺病毒感染则主要集中在每年的夏季;人偏肺病毒病毒感染则主要发生在每年的春季;人冠状病毒,人博卡病毒和人鼻病毒病毒感染的季节性特征有待进一步研究。发热呼吸道病毒多重感染率约为16.9%,人冠状病毒的混合感染所占比例最高,为86.5%。武汉及其在周边地区主要以上呼吸道感染为主,下呼吸道感染中排在前三位的依次是肺炎,支气管肺炎和支气管炎。临床症状主要以发热和咳嗽为主。
[Abstract]:This study collected samples of fever and respiratory tract from January 2010 to December 2015 in Wuhan and its surrounding areas, and detected influenza virus, respiratory syncytial virus, parainfluenza virus, human adenovirus, human coronavirus, human Boca virus by PCR and other methods. There are eight common febrile respiratory viruses, such as human metapulmonary virus and human rhinovirus. A total of 5387 specimens were collected in and around Wuhan between 2010 and 2015. The positive rate of any virus was 67.4%. The detection rates of eight pathogens were influenza virus (32.9%), respiratory syncytial virus (14.1%), human adenovirus (14.0%), parainfluenza virus (10.7%), human coronavirus (10.7%). Human rhinovirus (4.1%), human metapneumovirus (2.1%) and human Boca virus (1.4%). Overall, there is no statistical difference in the distribution of arbitrary viral infections between the sexes. But the distribution of influenza virus, human coronavirus and human rhinovirus infection is statistically different. The patient's age ranged from 0 to 89.2 years, with a median age of 2.0 years. The patients were further divided into eight different age groups according to their age (0-56-1112-2324-35-36-46-46-46-46-46-47-76-71 and over 72 years old). The number of detected samples was 3836443 / 309338203HZ 16563 and 30 persons respectively. The detection rate of any kind of virus in each age group was over 58%, and the detection rate of influenza virus was higher in people aged 12-36 years and those over 72 years old. The detection rate of respiratory syncytial virus and parainfluenza virus was the highest in adolescents aged 6-11 years, followed by children aged 0-5 years, and also in the elderly over 60 years old. The detection rate of human adenovirus and human coronavirus was the highest in the 0-5 age group, followed by the adolescents aged 6-11 years, and the higher detection rate among the elderly over 60 years old. The higher detection rate of human metapulmonary virus was found in children aged 0-5, adults aged 36-47 and elderly over 72 years old, and the detection rate of human Boca virus and human rhinovirus was the highest in children aged 0-5 years. Some febrile respiratory virus infection showed seasonal characteristics, influenza virus infection mainly occurred in spring and autumn, respiratory syncytial virus infection mainly concentrated in winter and spring every year. Parainfluenza virus infection is mainly concentrated in winter and summer, human adenovirus infection is concentrated in summer every year, human metapneumovirus infection mainly occurs in spring of each year, and parainfluenza virus infection mainly occurs in winter and summer each year. The seasonal characteristics of human coronavirus, human Boca virus and human rhinovirus infection need further study. The multiple infection rate of febrile respiratory tract virus was about 16.9%, and the proportion of mixed infection of human coronavirus was the highest (86.5%). In Wuhan and its surrounding areas, the upper respiratory tract infection is the main, the lower respiratory tract infection in the top three in the order of pneumonia, bronchopneumonia and bronchitis. The main clinical symptoms were fever and cough.
【学位授予单位】：武汉大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R56

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