呼吸机相关性肺炎患者病原菌分布与C-反应蛋白及降钙素原水平的影响研究

发布时间：2018-11-08 13:52

【摘要】：目的研究呼吸机相关性肺炎患者病原菌分布及C-反应蛋白(CRP)和降钙素原(PCT)水平的影响,为临床诊断与治疗提供参考。方法选择医院2011年2月-2014年5月诊治的170例呼吸机相关性肺炎患者为感染组,以同期使用呼吸机未感染患者110例为未感染组,健康体检者80名为对照组,分析感染患者的病原菌分布,采用酶联免疫吸附测定法检测患者感染病原菌后血清CRP和PCT及炎症因子的水平变化。结果 170例呼吸机相关性肺炎患者中分离病原菌187株,其中革兰阴性菌77株占41.18%,革兰阳性菌110株占58.82%;呼吸机相关性肺炎患者血清中PCT、CRP及炎症因子肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)及白细胞介素10(IL-10)水平明显高于对照组和未感染组,差异有统计学意义(P0.01)。结论呼吸机相关性肺炎患者感染病原菌以革兰阳性菌为主,且血清中PCT和CRP水平明显上升。
[Abstract]:Objective to study the distribution of pathogenic bacteria and the levels of C-reactive protein (CRP) and procalcitonin (PCT) in patients with ventilator-associated pneumonia and to provide reference for clinical diagnosis and treatment. Methods 170 patients with ventilator-associated pneumonia treated in hospital from February 2011 to May 2014 were selected as infection group, 110 patients who were not infected with ventilator and 80 healthy persons as control group. The distribution of pathogenic bacteria in infected patients was analyzed. The levels of serum CRP, PCT and inflammatory factors were detected by enzyme-linked immunosorbent assay (Elisa). Results 187 strains of pathogenic bacteria were isolated from 170 patients with ventilator-associated pneumonia, of which 77 were Gram-negative bacteria (41.18) and 110 Gram-positive bacteria (58.82). The serum levels of PCT,CRP, TNF- 伪, IL-6 and IL-10 in patients with ventilator-associated pneumonia were significantly higher than those in control group and uninfected group. The difference was statistically significant (P0.01). Conclusion Gram-positive bacteria were the main pathogens in patients with ventilator-associated pneumonia, and the levels of PCT and CRP in serum were significantly increased.
【作者单位】：中国医科大学绍兴医院检验科;
【基金】：浙江省科技厅基金资助项目[20140102(23)]
【分类号】：R563.1

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