替考拉宁治疗慢性阻塞性肺疾病患者革兰阳性菌感染的临床研究

发布时间：2018-11-10 22:21

【摘要】：目的研究替考拉宁治疗慢性阻塞性肺疾病(COPD)患者革兰阳性菌感染的疗效和安全性,为临床治疗提供参考依据。方法选择2012年3月-2013年6月92例COPD发生中、重度或高度怀疑为革兰阳性菌感染的患者,随机分为两组,观察组46例给予替考拉宁治疗,对照组46例给予万古霉素治疗,对替考拉宁与万古霉素治疗的临床效果和细菌清除效果进行评价,同时记录两组的不良反应,采用SPSS13.0进行统计分析。结果感染患者治疗总有效率观察组为89.13%、对照组为86.96%;细菌清除率观察组为84.78%、对照组为82.81%,两组比较差异无统计学意义;革兰阳性菌对替考拉宁及万古霉素的敏感率分别为94.87%、89.74%,两种抗菌药物敏感率比较差异无统计学意义;不良反应发生率观察组为2.17%、对照组为13.04%,两组不良反应比较差异有统计学意义(P0.05)。结论替考拉宁治疗COPD合并革兰阳性菌感染疗效显著,特别是对肠球菌属的敏感率较高,而且具有较高的安全性,对于高度怀疑肠球菌属、耐甲氧西林葡萄球菌等感染时,可优先考虑替考拉宁作为初始经验性抗菌药物。
[Abstract]:Objective to study the efficacy and safety of teicoplanin in the treatment of (COPD) patients with chronic obstructive pulmonary disease (COPD). Methods from March 2012 to June 2013, 92 patients with moderate or highly suspected Gram-positive bacilli infection in COPD were randomly divided into two groups: the observation group (n = 46) was treated with teicoplanin, and the control group (n = 46) was treated with vancomycin. The clinical efficacy and bacterial clearance of teicoplanin and vancomycin were evaluated. Adverse reactions were recorded and analyzed by SPSS13.0. Results the total effective rate was 89.13 in the observation group, 86.96 in the control group, 84.78 in the observation group and 82.81 in the control group. The sensitivity rates of Gram-positive bacteria to teicoplanin and vancomycin were 94.877.There was no significant difference between them. The incidence of adverse reactions was 2.17 in the observation group and 13.04in the control group. The difference between the two groups was statistically significant (P0.05). Conclusion the efficacy of teicoplanin in the treatment of COPD combined with Gram-positive bacteria infection is significant, especially the sensitive rate of teicoplanin to Enterococcus is higher, and it has higher safety. For highly suspected Enterococcus, methicillin-resistant Staphylococcus infection, etc. Teicoplanin may be given priority as an initial empirical antimicrobial agent.
【作者单位】：郑州人民医院呼吸内科;
【基金】：河南省卫生厅重点基金资助项目(HW-2010B-018)
【分类号】：R563.9

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