慢性阻塞性肺病患者夜间低氧血症相关预测因素分析

发布时间：2018-11-11 10:31

【摘要】：目的：研究慢性阻塞性肺疾病(COPD)患者夜间睡眠时低氧血症发生的可预测因素,以利早期诊断,早期治疗,延缓并发症的出现。方法：对安徽医科大学第三附属医院呼吸内科2010年6月至2011年12月确诊的45例COPD患者(排除睡眠呼吸暂停低通气综合征)的白天肺功能、动脉血气及夜间血氧水平与正常对照组(30名)进行比较和分析。结果： COPD患者夜间平均血氧饱和度(MSaO2)、夜间最低血氧饱和度(LSaO2)，，较正常人均有明显下降(P0.05)。从血氧分布情况来看,COPD患者睡眠时动脉血氧饱和度(Sa02)90%的时间占睡眠时间百分比(T90)亦显著高于正常人(P0.01)。相关分析表明,日间Sa02、一秒钟用力呼气容积(FEV1)绝对值与夜间MSaO2相关(r值依次0.704,0.435,P0.01)。建立了夜间血氧水平的预测公式：MSaO2(%)=0.536×日间Sa02(%)+2.35×FEV1绝对值(L)+38.805。日间SaO2、FEV1绝对值与夜间睡眠时血氧饱和度分布有关。结论： COPD患者睡眠时血氧饱和度较正常人出现明显下降,此时的血氧水平和分布可能通过日间SaO2、FEV1绝对值进行预测。
[Abstract]:Objective: to study the predictive factors of hypoxemia during night sleep in patients with chronic obstructive pulmonary disease (COPD) in order to facilitate early diagnosis and treatment and delay the occurrence of complications. Methods: the daytime lung function of 45 patients with COPD (excluding sleep apnea hypopnea syndrome) diagnosed in Department of Respiratory Medicine, third affiliated Hospital of Anhui Medical University from June 2010 to December 2011 was studied. Arterial blood gas and nocturnal blood oxygen levels were compared and analyzed with 30 normal controls. Results: the nocturnal mean oxygen saturation (MSaO2) and nocturnal minimum oxygen saturation (LSaO2) in COPD patients were significantly lower than those in normal controls (P0.05). According to the distribution of blood oxygen, the percentage of arterial oxygen saturation (Sa02) to sleep time (T90) in patients with COPD was significantly higher than that in normal subjects (P0.01). Correlation analysis showed that the absolute value of forced expiratory volume (FEV1) in daytime Sa02, was correlated with MSaO2 at night (r = 0.704 卤0.435, P0.01). The prediction formula of nocturnal blood oxygen level was established: MSaO2 (%) = 0.536 脳 day Sa02 (%) 2.35 脳 FEV1 absolute value (L) 38.805. The absolute value of daytime SaO2,FEV1 is related to the distribution of oxygen saturation during nighttime sleep. Conclusion: the level and distribution of blood oxygen in patients with COPD may be predicted by the absolute value of daytime SaO2,FEV1.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R563.9

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