老年肺结核患者肺部真菌感染的临床治疗分析

发布时间：2018-11-20 08:10

【摘要】：目的探讨老年肺结核患者肺部真菌感染的临床治疗方法及效果,为该病的治疗提供参考依据。方法选取医院2011年1月-2013年12月60例老年肺结核合并肺部真菌感染患者作为研究对象,将其随机分为研究组与对照组,各30例,对照组给予链霉素+乙胺丁醇治疗,研究组给予帕司烟肼+左氧氟沙星治疗,观察两组患者的临床治疗效果。结果研究组患者临床治疗总有效率、痰菌阴转率分别为93.3%、93.3%,均明显高于对照组患者的63.3%、60.0%,两组数据比较差异有统计学意义(P0.05);治疗后两组患者的白细胞计数、血小板计数、丙氨酸转氨酶、血尿酸指标均较治疗前有不同程度的改善,且研究组改善程度明显优于对照组,两组数据比较差异有统计学意义(P0.05)。结论临床对于老年肺结核合并肺部真菌感染患者在常规治疗基础上应用帕司烟肼与左氧氟沙星治疗方案是可行的,能显著提高复治肺结核的阴转率,值得临床应用与推广。
[Abstract]:Objective to explore the clinical treatment and effect of pulmonary fungal infection in elderly patients with pulmonary tuberculosis, and to provide reference for the treatment of pulmonary fungal infection. Methods from January 2011 to December 2013, 60 elderly pulmonary tuberculosis patients with pulmonary fungal infection were randomly divided into study group and control group (30 cases each). The control group was treated with streptomycin ethambutanol. The study group was treated with paisniazid levofloxacin, and the clinical effect of the two groups was observed. Results the total effective rate and sputum negative conversion rate of the patients in the study group were 93.3and 93.3respectively, which were significantly higher than that of the patients in the control group (63.3%). The difference between the two groups was statistically significant (P0.05). After treatment, the white blood cell count, platelet count, alanine aminotransferase and uric acid index of the two groups were improved to some extent, and the improvement degree of the study group was obviously better than that of the control group. The difference between the two groups was statistically significant (P0.05). Conclusion it is feasible for the elderly patients with pulmonary tuberculosis complicated with pulmonary fungal infection to use paisoniazide and levofloxacin on the basis of routine treatment. It can significantly improve the negative conversion rate of recurrent pulmonary tuberculosis and is worthy of clinical application and popularization.
【作者单位】：海南省农垦三亚医院感染科;
【基金】：海南省卫生厅科研基金资助项目(琼卫2011-9)
【分类号】：R521;R519

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