高迁移率族蛋白B1在重症肺炎患者中的临床研究
发布时间：2018-11-21 18:40
【摘要】：目的观察重症肺炎患者血清及肺泡灌洗液中高迁移率族蛋白B1(HMGBl)的水平及变化趋势,探讨其与重症肺炎患者病情严重程度的关系。方法选择2010年12月-2011年6月行机械通气的42例重症肺炎患者,将其预后分为存活组及死亡组;以同期14名健康体检者为阴性对照组,检测重症肺炎患者在入住重症医学科的第1、3、7天及转出ICU(或死亡)当天的血清及肺泡灌洗液中HMGBl、PCT水平及行APACHEⅡ评分;健康体检者体检时的血清HMGB1、PCT水平;根据原始数据录入SPSS13.0统计软件,以P0.05为差异有统计学意义。结果入住重症医学科第1天重症肺炎组血清HMGB1(172.10±15.32)μg/L高于对照组的(4.73±1.49)μg/L(P0.05);第3、7天及转科(死亡)当天,死亡组的血清和肺泡灌洗液HMGB1浓度分别为(202.41±20.98)、(218.86±25.42)、(225.37±24.30)μg/L及(8.79±1.91)、(10.87±1.31)、(12.08±1.85)μg/L,均高于存活组(P0.05);血清及肺泡灌洗液HMGB1水平存活组逐渐下降,死亡组逐渐上升;血清和肺泡灌洗液HMGB1水平与APACHEⅡ评分呈直线相关(r=0.334,P=0.009和r=0.298,P=0.031);血清与肺泡灌洗液HMGB1水平呈正相关(r=0.339,P=0.014)。结论基础APACHEⅡ评分越高预后越差,HMGB1水平能反映炎症及组织损伤的轻重程度,能协助评价病情、判断预后;重症肺炎患者局部及全身炎症反应存在有一定的关联性。
[Abstract]:Objective to observe the level and trend of high mobility group protein B1 (HMGBl) in serum and alveolar lavage fluid of patients with severe pneumonia, and to explore its relationship with the severity of severe pneumonia. Methods 42 patients with severe pneumonia who underwent mechanical ventilation from December 2010 to June 2011 were divided into survival group and death group. The serum and alveolar lavage fluid (HMGBl,PCT) levels and APACHE 鈪，
本文编号：2347936
[Abstract]:Objective to observe the level and trend of high mobility group protein B1 (HMGBl) in serum and alveolar lavage fluid of patients with severe pneumonia, and to explore its relationship with the severity of severe pneumonia. Methods 42 patients with severe pneumonia who underwent mechanical ventilation from December 2010 to June 2011 were divided into survival group and death group. The serum and alveolar lavage fluid (HMGBl,PCT) levels and APACHE 鈪，
本文编号：2347936
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