老年呼吸衰竭伴慢性肺心病患者血浆血小板活化因子及血小板功能的变化

发布时间：2018-11-24 17:06

【摘要】：目的观察老年呼吸衰竭伴慢性肺心病患者血小板活化因子(PAF)水平和血小板功能的变化。方法选取老年呼吸衰竭伴慢性肺心病患者70例为A组,另选取同期慢性肺心病患者70例为B组,健康体检者70例为对照组,应用血小板聚集仪检测血浆中PAF水平,检测血小板膜释放功能(GMP140)、血小板黏附功能(PADT)、血小板聚集功能(PAg T)水平,并对患者进行动脉血气检测。结果 A组、B组、对照组PAF水平分别为(178.3±19.4)、(152.8±1.5)、(132.1±8.6)μg/L,三组间两两比较,P均0.05。PADT、PAg T和GMP140水平比较A组B组对照组(P均0.05)。A组、B组、对照组动脉血氧分压分别为(47.5±8.2)、(54.2±7.6)、(60.1±9.3)mm Hg,动脉血二氧化碳分压分别为(50.2±8.6)、(44.2±7.6)、(36.3±8.5)mm Hg,三组间两两比较,P均0.05。结论老年呼吸衰竭伴慢性肺心病患者PAF水平升高,血小板黏附、聚集、膜释放功能增加。
[Abstract]:Objective to observe the changes of platelet activating factor (PAF) and platelet function in elderly patients with respiratory failure and chronic cor pulmonale. Methods 70 elderly patients with chronic cor pulmonale and respiratory failure were selected as group A, 70 patients with chronic pulmonary heart disease as group B and 70 healthy persons as control group. The level of PAF in plasma was detected by platelet aggregator. Platelet membrane release function (GMP140), platelet adhesion function (PADT), platelet aggregation function (PAg T) and arterial blood gas were measured. Results the levels of PAF in group A, group B and control group were (178.3 卤19.4), (卤1.5), (卤132.1 卤8.6) 渭 g / L, respectively. Comparison of PAg T and GMP140 levels in Group A and Group B (P < 0. 05) the partial pressure of oxygen in arterial blood was (47.5 卤8.2), () 54.2 卤7.6), (60.1 卤9.3) mm Hg,) in Group B, and Group B, respectively (47.5 卤8.2), (, 54.2 卤7.6), (, 60.1 卤9.3) mm Hg,). The partial pressure of carbon dioxide in arterial blood was (50.2 卤8.6), (, 44.2 卤7.6), (, 36.3 卤8.5) mm Hg, P < 0.05). Conclusion in elderly patients with respiratory failure and chronic cor pulmonale, the level of PAF increased, platelet adhesion, aggregation and membrane release function increased.
【作者单位】：海南省农垦总医院;
【基金】：海南省自然科学基金资助项目(2012-812172)
【分类号】：R541.5;R563.8

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