NT-proBNP、CTn-I的联合检测在急诊呼吸困难患者诊治中的应用
发布时间：2018-11-24 18:17
【摘要】：目的研究联合检测氨基末端B型钠尿肽原(NT-proBNP)和心肌肌钙蛋白-I(cTn-I)在急诊呼吸困难患者诊治中的作用。方法利用酶联免疫荧光法对送诊到本院急诊室的719例呼吸困难患者进行血浆NT-proBNP和cTn-I水平检测,比较心源性呼吸困难患者(主要为CHF患者)和非心源性呼吸困难患者血浆中NT-proBNP和cTn-I值的差别,并对检测结果进行统计分析。结果 285例心力衰竭患者(HF)血浆NT-proBNP中位数为4 218 ng/L(930 ng/L~13 225 ng/L),cTn-I中位数(四分位数)为8.12μg/L(1.02μg/L~18.22μg/L),明显高于434例非HF患者[NTproBNP中位数为123 ng/L(28 ng/L~509 ng/L)](P0.001),[cTn-I中位数为0.68μg/L(0.01μg/L~2.29μg/L)(P0.001)],差异具有统计学意义;血浆NT-proBNP诊断CHF的最佳阈值为900 ng/L,其敏感性为91%、特异性为86%,ROC曲线下面积为0.845,YOUDEN指数为0.77;联合检测NT-proBNP和cTn-I敏感性为99%,特异性为92%,优于单项检测。结论对于急诊室送诊的呼吸困难患者,及时进行NT-proBNP和cTn-I水平的联合检测在诊断和治疗中十分有价值。
[Abstract]:Objective to study the role of combined detection of amino-terminal B-type natriuretic peptide (NT-proBNP) and cardiac troponin I (cTn-I) in emergency patients with dyspnea. Methods the plasma levels of NT-proBNP and cTn-I in 719 patients with dyspnea were detected by enzyme-linked immunofluorescence (Elisa). The differences of plasma NT-proBNP and cTn-I between patients with cardiogenic dyspnea (mainly CHF) and non-cardiogenic dyspnea were compared and the results were statistically analyzed. Results the median of plasma NT-proBNP and cTn-I were 4 218 ng/L (930 ng/L~13 225 ng/L) and 8.12 渭 g / L (1.02 渭 g/L~18.22 渭 g / L) in 285 patients with heart failure. It was significantly higher than that in patients without HF [the median of NTproBNP was 123 ng/L (28 ng/L~509 ng/L)] (P0. 001), and the median of cTn-I was 0. 68 渭 g / L (0. 01 渭 g/L~2.29 渭 g / L) (P0. 001). The difference was statistically significant. The best threshold for the diagnosis of CHF by plasma NT-proBNP was 900 ng/L,. The sensitivity was 91 ng/L, and the specificity was 86. The area under the curve of ROC was 0. 845 and the index of YOUDEN was 0. 77. The sensitivity of combined detection of NT-proBNP and cTn-I was 99g and the specificity was 92.It was superior to single detection. Conclusion the combined detection of NT-proBNP and cTn-I in time is very valuable in the diagnosis and treatment of dyspnea patients in emergency room.
【作者单位】： 义乌市中心医院检验科;
【分类号】：R446.6;R56;R541.6
，
本文编号：2354559
[Abstract]:Objective to study the role of combined detection of amino-terminal B-type natriuretic peptide (NT-proBNP) and cardiac troponin I (cTn-I) in emergency patients with dyspnea. Methods the plasma levels of NT-proBNP and cTn-I in 719 patients with dyspnea were detected by enzyme-linked immunofluorescence (Elisa). The differences of plasma NT-proBNP and cTn-I between patients with cardiogenic dyspnea (mainly CHF) and non-cardiogenic dyspnea were compared and the results were statistically analyzed. Results the median of plasma NT-proBNP and cTn-I were 4 218 ng/L (930 ng/L~13 225 ng/L) and 8.12 渭 g / L (1.02 渭 g/L~18.22 渭 g / L) in 285 patients with heart failure. It was significantly higher than that in patients without HF [the median of NTproBNP was 123 ng/L (28 ng/L~509 ng/L)] (P0. 001), and the median of cTn-I was 0. 68 渭 g / L (0. 01 渭 g/L~2.29 渭 g / L) (P0. 001). The difference was statistically significant. The best threshold for the diagnosis of CHF by plasma NT-proBNP was 900 ng/L,. The sensitivity was 91 ng/L, and the specificity was 86. The area under the curve of ROC was 0. 845 and the index of YOUDEN was 0. 77. The sensitivity of combined detection of NT-proBNP and cTn-I was 99g and the specificity was 92.It was superior to single detection. Conclusion the combined detection of NT-proBNP and cTn-I in time is very valuable in the diagnosis and treatment of dyspnea patients in emergency room.
【作者单位】： 义乌市中心医院检验科;
【分类号】：R446.6;R56;R541.6
，
本文编号：2354559
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