热毒宁注射液治疗特发性肺纤维化急性加重临床疗效回顾性观察

发布时间：2018-12-09 13:29

【摘要】：目的:回顾性观察热毒宁注射液治疗特发性肺纤维化急性加重临床疗效。方法:收集2013年1月—2015年12月30例特发性肺纤维化(IPF)住院患,应用热毒宁中药注射液患者14例为治疗组,未应用的16例为对照组,疗程为10 d的临床试验。观察两组治疗前后中医症状积分、临床疗效、血常规、血气分析及肺功能的改善情况。结果:1在中医证候评分和临床疗效方面,治疗组治疗后中医症状评分及总积分除喘促气短、发热、面赤均较对照组改善明显(P0.05),总有效率较对照组明显好转;2在抗感染方面,治疗组治疗前后患者白细胞总数及中性粒细胞分类百分比,均较治疗前明显下降,其差异显著(P0.05),与对照组治疗后中性粒细胞分类百分比具有统计学差异(P0.05);3血气分析方面,治疗组治疗后血气分析Pa O2较对照组明显好转,其差异显著(P0.05);4在肺功能改善方面,治疗组治疗后患者DLCO明显高于对照组,统计学上有显著差异(P0.05)。结论:在IPF急性加重的治疗中,在西医基本治疗方案的基础上,辅以热毒宁注射液清热解毒化痰,能够明显改善患者临床症状,改善乏氧状态,提高弥散功能。
[Abstract]:Objective: to observe the clinical effect of Reduning injection on acute exacerbation of idiopathic pulmonary fibrosis. Methods: thirty patients with idiopathic pulmonary fibrosis (IPF) were collected from January 2013 to December 2015. 14 patients were treated with Reduning Chinese medicine injection and 16 patients were untreated as control group. The course of treatment was 10 days. The symptom score, clinical effect, blood routine, blood gas analysis and lung function were observed before and after treatment. Results: 1 in TCM syndromes score and clinical efficacy, the TCM symptom score and total score after treatment in the treatment group were significantly improved compared with the control group (P0.05), and the total effective rate was significantly improved compared with the control group. 2 in the aspect of anti-infection, the total number of leukocytes and the percentage of neutrophils in the treatment group were significantly lower than those before and after treatment (P0.05). The percentage of neutrophil classification in the control group was significantly different from that in the control group (P0.05). 3 in blood gas analysis, the blood gas analysis of Pa O 2 in the treatment group was significantly better than that in the control group (P0.05). 4 in the improvement of lung function, the DLCO in the treatment group was significantly higher than that in the control group (P0.05). Conclusion: in the treatment of acute aggravation of IPF, on the basis of the basic treatment plan of western medicine, it can obviously improve the clinical symptoms, improve the hypoxia state and improve the diffusion function by adding the heat clearing and detoxifying and resolving phlegm.
【作者单位】：彰武县中医医院;辽宁中医药大学附属医院;河南中医药大学第二附属医院;
【基金】：辽宁省中医临床重点学(专)科服务能力建设项目(2013-LNZYXZK-2)
【分类号】：R563.9

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