血清维生素D与哮喘患者病情控制程度及肺功能的关系

发布时间：2018-12-17 13:15

【摘要】：目的探讨哮喘患者血清维生素D水平与病情控制程度及肺功能的关系。方法哮喘患者66例作为哮喘组、健康体检者28例作为对照组,分别测定两组25羟维生素D[25(OH)D]水平。对哮喘组患者测定肺功能,并进行哮喘控制测试(ACT)评分。根据ACT评分将哮喘组分为控制组、部分控制组及未控制组。结果哮喘组血清25(OH)D水平明显低于对照组(P0.01),控制组明显高于未控制组(P0.05),部分控制组与控制组和未控制组比较差异无统计学意义(P0.05)。控制组第1秒用力肺呼气容积占肺活量百分比(FEV1%)预计值较部分控制组及未控制组均明显升高,两两比较均具有统计学差异(P0.05)。部分控制组及未控制组维生素D缺乏所占比例均较高,而控制组维生素D正常所占比例较高。不同控制水平的哮喘患者间血清25(OH)D水平分布差异无统计学意义(P0.05)。哮喘患者25(OH)D与肺功能参数FEV1%预计值之间存在正相关(r=0.643,P0.01)。结论哮喘患者血清维生素D普遍偏低,且与病情控制程度及肺功能相关。
[Abstract]:Objective to investigate the relationship between serum vitamin D level and severity of disease control and pulmonary function in asthmatic patients. Methods 66 asthmatic patients were used as asthma group and 28 healthy persons as control group. The levels of 25 hydroxyvitamin D [25 (OH) D] were measured in two groups. Lung function was measured in asthmatic group and (ACT) score was measured by asthma control test. According to ACT score, asthma group was divided into control group, partial control group and uncontrolled group. Results the level of serum 25 (OH) D in asthma group was significantly lower than that in control group (P0.01), and that in control group was significantly higher than that in uncontrolled group (P0.05). There was no significant difference between control group and control group (P0.05). Forced expiratory volume as a percentage of vital capacity (FEV1%) in control group was significantly higher than that in partial control group and non-control group (P0.05). The proportion of vitamin D deficiency in partial control group and control group was higher than that in control group, but the normal proportion of vitamin D in control group was higher than that in control group. There was no significant difference in the distribution of serum 25 (OH) D levels among asthma patients with different control levels (P0.05). There was a positive correlation between 25 (OH) D and FEV1% predictive value of pulmonary function parameters in asthmatic patients (r = 0. 643, P 0. 01). Conclusion Vitamin D in serum of asthmatic patients is generally low, and it is related to the degree of disease control and pulmonary function.
【作者单位】：吉林大学第一医院呼吸内科;
【分类号】：R562.25

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