人羊膜间充质干细胞治疗急性肺损伤的研究与进展

发布时间：2019-01-27 07:16

【摘要】：背景:近年来随着对干细胞功能特性不断深入的研究,干细胞已成为多种疾病治疗研究的热点领域。目的:综述人羊膜间充质干细胞移植治疗急性肺损伤的研究进展。方法:应用计算机检索2000年1月至2017年1月CNKI和Pub Med数据库相关文章,中文关键词为"人羊膜间充质干细胞,急性肺损伤",英文关键词为"mesenchymal stem cells,acute lung injury"。结果与结论:作为成体干细胞的重要成员,人羊膜间充质干细胞不仅具有多数其他干细胞所具备的优势和特性,还有来源广泛、操作无创且不违背伦理学等独特优点。人羊膜间充质干细胞可因炎症反应的驱动而归巢至受损组织,被促炎因子激活而旁分泌多种细胞因子,抑制中性粒细胞、巨噬细胞等免疫细胞的迁移及树突状细胞的成熟,减少NK细胞、B淋巴细胞和T淋巴细胞的增殖活化,上调抗炎因子和下调促炎因子的表达,还可通过抗氧化和抗细胞凋亡作用减轻肺泡炎性损伤;还可辅助修复或归巢致损伤部位定向分化并替代凋亡、坏死的细胞,为急性肺损伤的治疗提供了新思路。但急性肺损伤的致病因素众多且其病理生理过程十分复杂,人羊膜间充质干细胞移植治疗急性肺损伤仍有许多不足之处亟待解决。
[Abstract]:Background: in recent years, stem cells have become a hot area in the treatment of various diseases with the further research on the functional characteristics of stem cells. Objective: to review the progress of human amniotic mesenchymal stem cell transplantation in the treatment of acute lung injury. Methods: the relevant articles of CNKI and Pub Med databases were searched by computer from January 2000 to January 2017. The Chinese key words were "human amniotic mesenchymal stem cells, acute lung injury", and the English keyword was "mesenchymal stem cells,acute lung injury". Results & conclusion: as an important member of adult stem cells, human amniotic mesenchymal stem cells not only have the advantages and characteristics of most other stem cells, but also have the unique advantages of extensive sources, non-invasive operation and not contrary to ethics. Human amniotic mesenchymal stem cells can homing to damaged tissues because of the inflammatory response, activated by proinflammatory factors, paracrine many cytokines, inhibit the migration of neutrophils, macrophages and other immune cells and the maturation of dendritic cells. It can reduce the proliferation and activation of NK cells, B lymphocytes and T lymphocytes, up-regulate the expression of anti-inflammatory factor and down-regulate the expression of pro-inflammatory factor, and alleviate the alveolar inflammatory injury by anti-oxidation and anti-apoptosis. It can also assist repair or homing injury site differentiation and replace apoptotic and necrotic cells, which provides a new idea for the treatment of acute lung injury. However, there are many pathogenic factors of acute lung injury and its pathophysiological process is very complex, human amniotic mesenchymal stem cell transplantation in the treatment of acute lung injury still has many shortcomings to be solved.
【作者单位】：遵义医学院附属医院呼吸二科;
【基金】：贵州省科技计划课题(黔科合SY字[2015]3050):急性肺损伤病人肺保护的临床研究~~
【分类号】：R563.8

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