丹参川芎嗪对慢性阻塞性肺疾病急性加重合并呼吸衰竭患者肺功能及炎症因子的影响

发布时间：2019-02-17 14:35

【摘要】：目的探讨丹参川芎嗪注射液对慢性阻塞性肺疾病急性加重合并呼吸衰竭患者肺功能及炎症因子的影响。方法选择2011年6月至2014年12月就诊的老年慢性阻塞性肺疾病急性加重合并呼吸衰竭患者116例作为研究对象,随机分成两组,各58例。对照组:给予有创无创序贯机械通气和营养支持、祛痰止咳、扩张支气管、抗生素等基础治疗。观察组患者在接受给予有创无创序贯机械通气和营养支持、祛痰止咳、扩张支气管、抗生素等基础治疗的基础上,加用丹参川芎嗪注射液治疗。结果观察组总有效率96.55%高于对照组总有效率81.04%,差异具有统计学意义(P0.01)。治疗后,观察组血清IL-6(16.3±4.6)pg/ml、TNF-α(55.3±12.4)pg/ml及CRP(7.3±2.0)mg/L都低于对照组血清IL-6(25.1±7.2)pg/ml、TNF-α(79.6±20.5)pg/ml及CRP(22.5±4.7)mg/L,差异具有统计学意义(P0.01)。治疗后,观察组患者的Pa CO2(42.5±5.6)mm Hg低于对照组患者的Pa CO2(52.8±7.7)mm Hg,且观察组患者Pa O2(86.7±22.5)mm Hg高于对照组患者Pa O2(75.1±16.0)mm Hg,差异具有统计学意义(P0.01)。治疗后,观察组患者的PEF(4.91±0.87)L/s、FEV1(2.81±0.60)L、FVC(3.12±0.56)L高于对照组患者的PEF(3.99±0.64)L/s、FEV1(2.11±0.52)L、FVC(2.15±0.39)L,差异具有统计学意义(P0.01)。结论丹参川芎嗪注射液治疗老年慢性阻塞性肺疾病急性加重合并呼吸衰竭,能够减轻患者的炎症反应,改善患者的血气指标,促进患者肺功能的恢复。
[Abstract]:Objective to investigate the effects of salvia miltiorrhiza ligustrazine injection on pulmonary function and inflammatory factors in patients with acute exacerbation of chronic obstructive pulmonary disease and respiratory failure. Methods 116 elderly patients with acute exacerbation of chronic obstructive pulmonary disease complicated with respiratory failure from June 2011 to December 2014 were randomly divided into two groups: 58 cases in each group. The control group was treated with noninvasive sequential mechanical ventilation and nutritional support, expectorant and cough relief, bronchiectasis, antibiotics and so on. The patients in the observation group were treated with salvia miltiorrhiza ligustrazine injection on the basis of the treatment of invasive and noninvasive sequential mechanical ventilation and nutritional support, expectorant and cough relief, bronchiectasis, antibiotics and so on. Results the total effective rate in the observation group was 96.55% higher than that in the control group (81.04%, P 0.01). After treatment, serum IL-6 (16.3 卤4.6) pg/ml,TNF- 伪 (55.3 卤12.4) pg/ml and CRP (7.3 卤2.0) mg/L in the observation group were lower than those in the control group (25.1 卤7.2) pg/ml,. The difference of TNF- 伪 (79.6 卤20.5) pg/ml and CRP (22.5 卤4.7) mg/L, was statistically significant (P0.01). After treatment, Pa CO2 (42.5 卤5.6) mm Hg) in the observation group was lower than that in the control group (52.8 卤7.7) mm Hg,), and Pa O2 (86.7 卤22.5) mm Hg) in the observation group was higher than that in the control group (75.1 卤16.0) mm Hg,). The difference was statistically significant (P0.01). After treatment, the PEF of patients in observation group (4.91 卤0.87) L / s FEV1 (2.81 卤0.60) L FVC (3.12 卤0.56) L was higher than that in control group (3.99 卤0.64) L / s FEV1 (2.11 卤0.52) L, respectively. FVC (2.15 卤0.39) L, the difference was statistically significant (P0.01). Conclusion Salvia miltiorrhiza ligustrazine injection in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease combined with respiratory failure can reduce the inflammatory reaction of patients improve the blood gas index and promote the recovery of pulmonary function.
【作者单位】：襄阳市中心医院急诊科;
【基金】：襄阳市研究开发计划项目(No.鄂科计〔2011〕5-127)
【分类号】：R563.9;R563.8

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