β2受体激动剂可显著增加自发性气道阻塞哮喘患者呼出气一氧化氮水平

发布时间：2019-03-30 16:26

【摘要】：目的评价吸入β2受体激动剂对自发的气流阻塞哮喘患者FENO的影响。方法入选南方医院支气管舒张实验阳性的20例初诊哮喘患者和13例COPD患者,比较吸入400μg的沙丁胺醇后FeNO及肺功能改变,评价肺功能与FeNO及痰炎症细胞关系。结果 COPD患者诱导痰以中性粒细胞为主,初治哮喘患者诱导痰以嗜酸粒细胞为主。舒张前后FeNO水平哮喘组均显著高COPD组(P0.05)。哮喘组吸入舒张剂后FeNO明显增高(P0.05),COPD组未见显著差异。然而,吸入沙丁胺醇后FEV1%、FEV1%的改善率及其增加的绝对值(mL)与舒张前、舒张后的FeNO值,以及FeNO前后的改变值均未发现有显著相关关系。结论β2受体激动剂可以增加存在气流阻塞初治哮喘患者FeNO水平,其意义需进一步探讨。
[Abstract]:Objective to evaluate the effects of inhaled 尾 2 receptor agonists on FENO in patients with spontaneous airflow obstruction. Methods the changes of FeNO and pulmonary function after inhaling 400 渭 g salbutamol were compared in 20 newly diagnosed asthma patients and 13 COPD patients with positive bronchodilation test in Southern Hospital. The relationship between pulmonary function and FeNO and sputum inflammatory cells was evaluated. Results neutrophils were the main induced sputum in COPD patients, eosinophils were the main induced sputum in asthma patients. Pre-and post-diastolic FeNO levels in asthma group were significantly higher than those in COPD group (P0.05). There was no significant difference in FeNO of asthma group after inhaling relaxant (P0.05), COPD group). However, there was no significant correlation between the improvement rate of FEV1%,FEV1% after inhaling salbutamol and the absolute value of (mL) before and after relaxation, as well as the change value of Feno before and after relaxation, as well as before and after FeNO. Conclusion 尾 2 receptor agonists can increase the level of FeNO in patients with primary asthma due to airflow obstruction, and the significance of 尾 2 receptor agonists should be further studied.
【作者单位】：南方医科大学南方医院呼吸与危重医学科慢性气道疾病实验室;
【分类号】：R562.25

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