小青龙汤联合西药治疗老年慢性阻塞性肺疾病发作期的临床疗效及免疫调节作用

发布时间：2019-03-30 17:05

【摘要】：目的探讨小青龙汤联合西药治疗老年慢性阻塞性肺疾病发作期的临床疗效及对免疫功能的调节作用。方法 152例老年慢性阻塞性肺疾病发作期患者随机分为两组,观察组76例采用小青龙汤联合西药治疗,对照组76例仅采用西药治疗,比较两组的疗效以及肺功能、血气分析和细胞因子的变化。结果观察组的显效率和总有效率分别为59.2%和93.4%,均明显高于对照组的26.3%、76.3%(P0.05)。观察组咳嗽、咯痰、喘息和乏力的缓解时间明显少于对照组(P0.05)。与治疗前比较,两组治疗后FEV1、FEV1/FVC、FEF75%和PaO_2水平均明显升高(P0.05),而PaCO_2水平明显降低(P0.05)。并且,观察组治疗后FEV1、FEV1/FVC、FEF75%和PaO_2水平明显高于同期对照组水平(P0.05),而PCO_2水平明显低于对照组(P0.05)。观察组治疗后IL-4、IL-8、TNF-α水平明显低于同期对照组水平(P0.05),IFN-γ水平明显高于对照组(P0.05)。结论小青龙汤联合西药治疗老年慢性阻塞性肺疾病发作期能够明显提高临床疗效,改善患者的肺功能、血气,并且可调节患者的免疫功能。
[Abstract]:Objective to investigate the clinical efficacy of Xiaoqinglong decoction combined with western medicine in the treatment of senile chronic obstructive pulmonary disease (COPD) during the attack period and its regulating effect on immune function. Methods 152 elderly patients with chronic obstructive pulmonary disease were randomly divided into two groups. The observation group (76 cases) were treated with Xiaoqinglong decoction and western medicine, while the control group (76 cases) were treated only with western medicine. The curative effect and pulmonary function of the two groups were compared. Blood gas analysis and cytokine changes. Results the effective rate and total effective rate in the observation group were 59.2% and 93.4% respectively, which were significantly higher than those in the control group (26.3%, 76.3%) (P0.05). The remission time of cough, expectoration, wheezing and fatigue in the observation group was significantly shorter than that in the control group (P0.05). Compared with pre-treatment, the levels of FEV1,FEV1/FVC,FEF75% and PaO_2 in the two groups increased significantly (P0.05), while the level of PaCO_2 decreased significantly (P0.05). In addition, the levels of FEV1,FEV1/FVC,FEF75% and PaO_2 in the observation group after treatment were significantly higher than those in the control group (P0.05), while the level of PCO_2 was significantly lower than that in the control group (P0.05). The level of IL-4,IL-8,TNF- 伪 in the observation group was significantly lower than that in the control group after treatment (P0.05), and the level of IFN- 纬 was significantly higher than that in the control group (P0.05). Conclusion Xiaoqinglong decoction combined with western medicine can significantly improve the clinical efficacy, improve the pulmonary function, blood gas, and regulate the immune function of the elderly patients with chronic obstructive pulmonary disease.
【作者单位】：新余市人民医院中医科;
【分类号】：R56

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