肺表面活性物质蛋白基因多态性与慢性阻塞性肺疾病易感性关联的Meta分析
发布时间：2019-04-09 11:53
【摘要】：目的探讨肺表面活性物质蛋白(SP)相关基因多态性与慢性阻塞性肺疾病(COPD)的关联。方法检索万方数据、维普、Google学术、PubMed、CNKI、CBM、EMBASE、Web of Science等电子数据库,检索范围从建库至2013年9月,采用Stata12.0进行Meta分析。结果本研究共计纳入7项病例对照研究,包括1279例COPD患者和1482名健康对照人群。SP-A基因多态性与COPD易感性增加有关(等位基因模型OR=1.53,95%CI:1.14~2.05,P=0.005;显性模型OR=1.65,95%CI:1.02~2.69,P=0.043;隐性模型OR=1.66,95%CI:1.17~2.35,P=0.005;纯合子模型OR=2.06,95%CI:1.24~3.41,P=0.005;杂合子模型OR=1.59,95%CI:1.13~2.22,P=0.007),但SP-B和SP-D基因多态性均与COPD易感性关联无统计学意义(均P0.05)。亚组分析表明,SP-A基因多态性与亚洲人群COPD易感性增加关系密切,但与欧美人群无关。结论 SP-A基因多态性可能与亚洲人群COPD易感性增加有关。
[Abstract]:Objective to investigate the association between pulmonary surfactant protein (SP)-associated gene polymorphism and chronic obstructive pulmonary disease (COPD) (COPD). Methods the electronic databases, such as Wanfang data, Vip, Google academic and PubMed,CNKI,CBM,EMBASE,Web of Science, were retrieved from September 2013 to September 2013. Meta analysis was carried out by Stata12.0. Results this study included 7 case-control studies, including 1279 COPD patients and 1482 healthy controls. Sp-A gene polymorphism was associated with increased susceptibility to COPD (allele model OR=1.53,95%CI:1.14~2.05,P=0.005;). Dominant model OR=1.65,95%CI:1.02~2.69,P=0.043; recessive model OR=1.66,95%CI:1.17~2.35,P=0.005; homozygote model OR=2.06,95%CI:1.24~3.41,P=0.005; Heterozygote model OR=1.59,95%CI:1.13~2.22,P=0.007), but there was no significant correlation between SP-B and SP-D gene polymorphism and susceptibility to COPD (P0.05). Subgroup analysis showed that SP-A gene polymorphism was closely associated with increased susceptibility to COPD in Asian population, but not with European and American population. Conclusion SP-A gene polymorphism may be associated with increased susceptibility to COPD in Asian population.
【作者单位】： 大连医科大学附属第一医院呼吸内科;大连大学附属中山医院;大连医科大学附属第一医院消化内科;
【基金】：辽宁省教育厅科技研究项目(No.ZX13017)
【分类号】：R563.9
，
本文编号：2455156
[Abstract]:Objective to investigate the association between pulmonary surfactant protein (SP)-associated gene polymorphism and chronic obstructive pulmonary disease (COPD) (COPD). Methods the electronic databases, such as Wanfang data, Vip, Google academic and PubMed,CNKI,CBM,EMBASE,Web of Science, were retrieved from September 2013 to September 2013. Meta analysis was carried out by Stata12.0. Results this study included 7 case-control studies, including 1279 COPD patients and 1482 healthy controls. Sp-A gene polymorphism was associated with increased susceptibility to COPD (allele model OR=1.53,95%CI:1.14~2.05,P=0.005;). Dominant model OR=1.65,95%CI:1.02~2.69,P=0.043; recessive model OR=1.66,95%CI:1.17~2.35,P=0.005; homozygote model OR=2.06,95%CI:1.24~3.41,P=0.005; Heterozygote model OR=1.59,95%CI:1.13~2.22,P=0.007), but there was no significant correlation between SP-B and SP-D gene polymorphism and susceptibility to COPD (P0.05). Subgroup analysis showed that SP-A gene polymorphism was closely associated with increased susceptibility to COPD in Asian population, but not with European and American population. Conclusion SP-A gene polymorphism may be associated with increased susceptibility to COPD in Asian population.
【作者单位】： 大连医科大学附属第一医院呼吸内科;大连大学附属中山医院;大连医科大学附属第一医院消化内科;
【基金】：辽宁省教育厅科技研究项目(No.ZX13017)
【分类号】：R563.9
，
本文编号：2455156
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