N-乙酰半胱氨酸治疗特发性肺纤维化疗效的系统评价
发布时间：2019-05-24 06:10
【摘要】：目的:系统评价N-乙酰半胱氨酸(NAC)治疗特发性肺纤维化(IPF)的疗效,为临床提供循证参考。方法:计算机检索Central数据库、Pub Med、EMBase、中国生物医学文献数据库、相关期刊论文、万方数据库和中文科技期刊数据库,收集NAC(不限单药或联用)对比安慰剂/空白对照治疗IPF的随机对照试验(RCT)及半随机对照试验(q RCT),提取资料并采用Cochrane协作网提供的偏倚风险评价工具(2014年版)评价质量后,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入10项研究(2项RCT,8项q RCT),合计742例患者。Meta分析结果显示,与安慰剂/空白对照相比,使用NAC无法降低IPF患者的死亡率[OR=1.14,95%CI(0.50,2.62),P=0.76],但可以显著提高IPF患者主症状缓解率[OR=3.17,95%CI(1.98,5.07),P0.001],改善患者呼吸困难评分[SMD=-2.54,95%CI(-5.02,-0.06),P=0.04]。结论:NAC治疗IPF不能降低患者的死亡率,但可以缓解患者的主症状,改善呼吸困难。
[Abstract]:Objective: to systematically evaluate the efficacy of N-acetylcystine (NAC) in the treatment of (IPF) with Idiopathic pulmonary fibrosis and to provide evidence-based reference for clinic. Methods: Central database, Pub Med,EMBase, Chinese biomedical literature database, Chinese periodical full-text database, Wanfang database and Chinese sci-tech periodical database were searched by computer. Collection of NAC (unlimited single drug or combination) versus placebo / blank control treatment of IPF randomized controlled trial (RCT) and semi-randomized controlled trial (q RCT), After extracting the data and evaluating the quality by using the bias risk assessment tool provided by Cochrane collaboration network (2014 edition), the Meta analysis was carried out by using Rev Man 5.3 statistical software. Results: a total of 10 studies (2 RCT,8 items q RCT), total 742 patients) were included. Meta-analysis showed that NAC could not reduce mortality in patients with IPF compared with placebo / blank control [OR=1.14,95%CI (0.50,2.62). P 鈮，
本文编号：2484622
[Abstract]:Objective: to systematically evaluate the efficacy of N-acetylcystine (NAC) in the treatment of (IPF) with Idiopathic pulmonary fibrosis and to provide evidence-based reference for clinic. Methods: Central database, Pub Med,EMBase, Chinese biomedical literature database, Chinese periodical full-text database, Wanfang database and Chinese sci-tech periodical database were searched by computer. Collection of NAC (unlimited single drug or combination) versus placebo / blank control treatment of IPF randomized controlled trial (RCT) and semi-randomized controlled trial (q RCT), After extracting the data and evaluating the quality by using the bias risk assessment tool provided by Cochrane collaboration network (2014 edition), the Meta analysis was carried out by using Rev Man 5.3 statistical software. Results: a total of 10 studies (2 RCT,8 items q RCT), total 742 patients) were included. Meta-analysis showed that NAC could not reduce mortality in patients with IPF compared with placebo / blank control [OR=1.14,95%CI (0.50,2.62). P 鈮，
本文编号：2484622
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