肠黏膜屏障功能对老年重症慢性阻塞性肺疾病患者预后评估的临床意义
发布时间：2019-06-11 09:10
【摘要】：目的探讨肠黏膜屏障功能在老年重症慢性阻塞性肺疾病(COPD)患者预后评估中的临床意义。方法选取老年COPD合并呼吸衰竭并给予有创机械通气患者53例,根据病情转归分为存活组35例、死亡组18例;测定给予机械通气治疗0、72 h的静脉血D-乳酸、二胺氧化酶(DAO)及急性生理与慢性健康状况(APACHE)Ⅱ评分。分析肠黏膜屏障功能变化与预后的关系。结果与对照组相比,死亡组与存活组入组时APACHEⅡ评分、血清D-乳酸、DAO明显升高(P0.05);入组时死亡组与存活组比较,APACHEⅡ评分、血清D-乳酸、DAO略有升高,但无统计学差异(P0.05);治疗72 h后,存活组与死亡组APACHEⅡ评分、血清D-乳酸、DAO都较治疗前下降,存活组下降程度更显著(P0.05)。相关分析显示COPD合并呼吸衰竭患者血清D-乳酸、DAO水平与APACHEⅡ评分明显正相关。结论老年重症COPD患者肠黏膜屏障功能可作为判断病情严重程度、观察疗效和评估预后的指标之一。
[Abstract]:Objective To study the clinical significance of intestinal mucosal barrier function in the prognosis of elderly patients with severe chronic obstructive pulmonary disease (COPD). Methods 53 patients with COPD combined with respiratory failure were selected, and 53 patients with invasive mechanical ventilation were divided into the survival group (35 cases) and the death group (18 cases) according to the outcome of the disease. The D-lactic acid was measured by mechanical ventilation for 0 and 72 hours. Diamine oxidase (DAO) and acute physiology and chronic health (APACHE) 鈪，
本文编号：2497078
[Abstract]:Objective To study the clinical significance of intestinal mucosal barrier function in the prognosis of elderly patients with severe chronic obstructive pulmonary disease (COPD). Methods 53 patients with COPD combined with respiratory failure were selected, and 53 patients with invasive mechanical ventilation were divided into the survival group (35 cases) and the death group (18 cases) according to the outcome of the disease. The D-lactic acid was measured by mechanical ventilation for 0 and 72 hours. Diamine oxidase (DAO) and acute physiology and chronic health (APACHE) 鈪，
本文编号：2497078
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