慢性阻塞性肺疾病患者血清肺表面活性蛋白D、降钙素原、C-反应蛋白检测的临床意义
发布时间：2019-06-17 17:03
【摘要】：目的:探讨血清肺表面活性蛋白D(surfactant protein D,SP-D)、降钙素原(procalcitonin,PCT)、C-反应蛋白(C-reactive protein,CRP)三种血清学炎症标志物浓度变化与慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的关系,寻找一种高效敏感的血清炎症标志物,指导慢性阻塞性肺疾病急性加重期(acute exacerbations of chronic obstructive pulmonary disease,AECOPD)患者抗炎药物应用和肺功能分级。方法:选择40例AECOPD患者,COPD稳定期患者40例为试验组,其中,AECOPD组患者中有20例肺功能分级为GOLD1~2级,20例肺功能分级为GOLD3~4级,健康体检者40例为对照组,检测三种血清学标志物水平。结果:1、AECOPD组、COPD稳定期组、健康血清血清SP-D水平分别为(24.19±2.67)ng/L、(20.77±1.17)ng/L、(18.84±1.11)ng/L;PCT水平为(714.28±185.73)ng/L、(405.38±43.63)ng/L、(388.28±34.24)ng/L;CRP水平为(52.45±9.54)mg/L、(8.72±2.65)mg/L、(7.85±2.24)mg/L,COPD稳定期组和健康对照组血清SP-D、PCT、CRP浓度明显低于AECOPD组,差异均有统计学意义(P0.05),血清PCT、CRP水平在COPD稳定期组高于健康对照组,但差异无统计学意义(P0.05),2.SP-D水平在AECOPD GOLD 1~2级组(22,15±1.71)ng/L低于GOLD3~4级组(26.23±1.77)ng/L,差异明显有统计学意义(P0.05)。3.AECOPD组患者SP-D水平与PCT呈正相关性(相关系数r=0.333,P0.05),但与CRP无相关性(r=-0.284,P0.05),PCT与CRP也无相关性(r=0.016,P0.05)。结论:1.血清SP-D、PCT、CRP在COPD急性加重期明显升高,COPD稳定期SP-D有所下降,SP-D、PCT、CRP是反映COPD急性加重的炎症指标。2.AECOPD患者血清SP-D水平可以反应气道阻塞严重程度,指导临床医生选择吸入制剂的应用。3.血清SP-D与PCT水平在COPD急性加重期表现为正相关性,而与CRP却无相关性,PCT与CRP也无相关性。
[Abstract]:Objective: To study the relationship between serum pulmonary surfactant protein D (SP-D), procalcitonin (PCT), C-reactive protein (CRP) and chronic obstructive pulmonary disease (COPD). To find an effective and sensitive serum inflammatory marker to guide the application of anti-inflammatory and pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods:40 patients with AECOPD and 40 patients with stable COPD were selected as the test group, among which,20 of the patients with AECOPD were classified as GOLD1-2,20 cases of lung function were classified as GOLD3-4, and 40 healthy subjects were control group, and the level of three serological markers was detected. Results: The levels of SP-D were (24.19-2.67) ng/ L, (20.77-1.17) ng/ L, (18.84-1.11) ng/ L, (714.28-185.73) ng/ L, (405.38-43.63) ng/ L, (388.28-34.24) ng/ L, and CRP levels (52.45-9.54) mg/ L, (8.72-2.65) mg/ L, respectively. (7.85-2.24) mg/ L, the concentrations of SP-D, PCT and CRP in the stable and healthy controls were significantly lower than those in the AECOPD group (P0.05). The level of SP-D in the AECOPD group was lower than that of the GOLD3-4 group (26.23-1.77) ng/ L (P <0.05). The SP-D level in the AECOPD group was positively correlated with PCT (r = 0.333, P0.05), but not related to CRP (r =-0.284, P0.05). There was no correlation between PCT and CRP (r = 0.016, P0.05). Conclusion:1. Serum SP-D, PCT, and CRP were significantly elevated in the acute exacerbation of COPD, and the SP-D in the stable period of COPD decreased, and SP-D, PCT and CRP were the index of inflammation that reflected the acute exacerbation of COPD. Serum SP-D and PCT level showed positive correlation in acute exacerbation of COPD, and there was no correlation with CRP, and there was no correlation between PCT and CRP.
【学位授予单位】：蚌埠医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R563.9
本文编号：2501134
[Abstract]:Objective: To study the relationship between serum pulmonary surfactant protein D (SP-D), procalcitonin (PCT), C-reactive protein (CRP) and chronic obstructive pulmonary disease (COPD). To find an effective and sensitive serum inflammatory marker to guide the application of anti-inflammatory and pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods:40 patients with AECOPD and 40 patients with stable COPD were selected as the test group, among which,20 of the patients with AECOPD were classified as GOLD1-2,20 cases of lung function were classified as GOLD3-4, and 40 healthy subjects were control group, and the level of three serological markers was detected. Results: The levels of SP-D were (24.19-2.67) ng/ L, (20.77-1.17) ng/ L, (18.84-1.11) ng/ L, (714.28-185.73) ng/ L, (405.38-43.63) ng/ L, (388.28-34.24) ng/ L, and CRP levels (52.45-9.54) mg/ L, (8.72-2.65) mg/ L, respectively. (7.85-2.24) mg/ L, the concentrations of SP-D, PCT and CRP in the stable and healthy controls were significantly lower than those in the AECOPD group (P0.05). The level of SP-D in the AECOPD group was lower than that of the GOLD3-4 group (26.23-1.77) ng/ L (P <0.05). The SP-D level in the AECOPD group was positively correlated with PCT (r = 0.333, P0.05), but not related to CRP (r =-0.284, P0.05). There was no correlation between PCT and CRP (r = 0.016, P0.05). Conclusion:1. Serum SP-D, PCT, and CRP were significantly elevated in the acute exacerbation of COPD, and the SP-D in the stable period of COPD decreased, and SP-D, PCT and CRP were the index of inflammation that reflected the acute exacerbation of COPD. Serum SP-D and PCT level showed positive correlation in acute exacerbation of COPD, and there was no correlation with CRP, and there was no correlation between PCT and CRP.
【学位授予单位】：蚌埠医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R563.9
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