喜炎平注射液辅助治疗支气管哮喘及对患者血浆内皮素、一氧化氮及肿瘤坏死因子-α的影响

发布时间：2019-08-06 19:04

【摘要】：目的:探讨喜炎平注射液辅助治疗支气管哮喘及对患者血浆内皮素-1(ET-1)、一氧化氮(NO)的影响。方法:180例支气管哮喘患儿,随机分成观察组和对照组。对照组给予常规治疗。观察组在对照组常规治疗方式的基础上,给予喜炎平注射液。结果:治疗后,观察组总有效率91.11%优于对照组75.56%,差异具有显著性(P0.05)。治疗后,观察组中医证候评分(7.5±2.1)分、哮喘控制测试评分(18.5±4.2)分低于对照组中医证候评分(10.7±2.8)分)、哮喘控制测试评分(16.7±4.5)分,差异有统计学意义(P0.01)。治疗后,观察组吸入支气管扩张剂次数(2.4±1.1)次低于对照组吸入支气管扩张剂次数(3.1±0.8)次,差异有统计学意义(P0.01)。治疗后,观察组患者PEF50指标高于对照组,差异具有统计学意义(P0.05)。治疗后,两组血浆ET-1和NO均低于治疗前,差异具有显著性(P0.05)。治疗1月后,观察组支气管哮喘患儿血浆ET-1和NO水平(109.5±33.1)pg/m L、(99.5±31.2)μmol/L低于对照组支气管哮喘患儿血浆ET-1和NO水平(135.7±41.8)pg/m L、(119.7±32.5)μmol/L,差异均有统计学意义(P0.05)。结论:喜炎平注射液辅助治疗支气管哮喘患儿疗效显著,可明显改善患者的血浆ET-1、NO水平。
[Abstract]:Objective: to investigate the effect of Xiyanping injection on plasma Endothelin-1 (ET-1) and nitric oxide (NO) in patients with bronchial asthma. Methods: 180 children with bronchial asthma were randomly divided into observation group and control group. The control group was given routine treatment. The observation group was given Xiyanping injection on the basis of routine treatment in the control group. Results: after treatment, the total effective rate of the observation group was 91.11%, which was significantly better than that of the control group (75.56%) (P 0.05). After treatment, the scores of TCM syndrome, asthma control test and asthma control test in the observation group were (7.5 卤2.1), (18.5 卤4.2) and (10.7 卤2.8), (16.7 卤4.5), respectively (P 0.01). After treatment, the times of inhaling bronchodilators in the observation group (2.4 卤1.1) were significantly lower than those in the control group (3.1 卤0.8) (P 0.01). After treatment, the PEF50 index of the observation group was higher than that of the control group, the difference was statistically significant (P 0.05). After treatment, plasma ET-1 and NO in the two groups were significantly lower than those before treatment (P 0.05). After 1 month of treatment, the plasma levels of ET-1 and NO in the observation group were (109.5 卤33.1) pg/m / L, (99.5 卤31.2) 渭 mol/L were significantly lower than those in the control group (135.7 卤41.80) pg/m / L, and (119.7 卤32.5) 渭 mol/L, were significantly different (P 0.05). Conclusion: Xiyanping injection is effective in the treatment of bronchial asthma and can significantly improve the plasma ET-1,NO level.
【作者单位】：湖州市第一人民医院(湖州市师范学院附属第一医院)儿科;
【基金】：湖州市科技计划项目(2009YSB15)
【分类号】：R562.25

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